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Compound Detail

CHEMBL1814273

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CC(=O)O.O=C1CNC(=O)N1Cc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1

Basic Information

ChEMBL ID CHEMBL1814273
Phase Preclinical
Structure Type MOL
InChI Key YRHXWEBFYLMDDL-YCBFMBTMSA-N
Parent Compound CHEMBL1851850
Active Moiety CHEMBL1851850
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

527.7
MW (Da)
3.16
ALogP
7
HBA
5
HBD
131.4
PSA (Ų)
0.15
QED
1
Ro5 Violations
18
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C31H45N3O8
MW 587.71
Aromatic Rings 2
Heavy Atoms 38
NP-Likeness -0.25

Activity Summary

EC50 3 meas. best 8.9

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-2 adrenergic receptor
CHEMBL210
EC50 8.9 8.9 1.3 1
Beta-3 adrenergic receptor
CHEMBL246
EC50 7.4 7.4 39.8 1
Beta-1 adrenergic receptor
CHEMBL213
EC50 6.9 6.9 125.9 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
21696967 10.1016/j.bmc.2011.05.064 Beta-2 adrenergic receptor 2
21696967 10.1016/j.bmc.2011.05.064 Beta-1 adrenergic receptor 1
21696967 10.1016/j.bmc.2011.05.064 Beta-3 adrenergic receptor 1
21696967 10.1016/j.bmc.2011.05.064 Liver microsomes 1

Data from ChEMBL 36 via Core Engine