Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL1814272

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
CC(=O)O.O=C1CN(c2cccc(CCCCOCCCCCCNC[C@H](O)c3ccc(O)c(CO)c3)c2)C(=O)N1

Basic Information

ChEMBL ID CHEMBL1814272
Phase Preclinical
Structure Type MOL
InChI Key MANYGYLFJSXIDV-SNYZSRNZSA-N
Parent Compound CHEMBL1851849
Active Moiety CHEMBL1851849
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

513.6
MW (Da)
3.16
ALogP
7
HBA
5
HBD
131.4
PSA (Ų)
0.16
QED
1
Ro5 Violations
17
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C30H43N3O8
MW 573.69
Aromatic Rings 2
Heavy Atoms 37
NP-Likeness -0.10

Activity Summary

EC50 4 meas. best 8.6

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-2 adrenergic receptor
CHEMBL210
EC50 8.6 8.6 2.5 1
Beta-2 adrenergic receptor
CHEMBL5414
EC50 8.6 8.6 2.5 1
Beta-1 adrenergic receptor
CHEMBL213
EC50 6.7 6.7 199.5 1
Beta-3 adrenergic receptor
CHEMBL246
EC50 6.5 6.5 316.2 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
21696967 10.1016/j.bmc.2011.05.064 Beta-2 adrenergic receptor 6
21696967 10.1016/j.bmc.2011.05.064 Beta-1 adrenergic receptor 1
21696967 10.1016/j.bmc.2011.05.064 Beta-3 adrenergic receptor 1
21696967 10.1016/j.bmc.2011.05.064 Liver microsomes 1

Data from ChEMBL 36 via Core Engine