Assay Detail
Functional
CHEMBL1816603
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at adrenergic beta2 receptor in guinea pig trachea assessed as inhibition of electrically-stimulated contraction
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The discovery of long-acting saligenin β₂ adrenergic receptor agonists incorporating hydantoin or uracil rings.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 9.03 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1814278 | — | — | 1 | 9.70 |
| CHEMBL1256786 | FORMOTEROL | 4.0 | 1 | 9.50 |
| CHEMBL1814268 | — | — | 1 | 9.10 |
| CHEMBL1814280 | — | — | 1 | 9.00 |
| CHEMBL1814272 | — | — | 1 | 8.60 |
| CHEMBL1263 | SALMETEROL | 4.0 | 1 | 8.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1814278 | — | EC50 | = | 0.1995 | nM | 9.70 |
| CHEMBL1256786 | FORMOTEROL | EC50 | = | 0.3162 | nM | 9.50 |
| CHEMBL1814268 | — | EC50 | = | 0.7943 | nM | 9.10 |
| CHEMBL1814280 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1814272 | — | EC50 | = | 2.512 | nM | 8.60 |
| CHEMBL1263 | SALMETEROL | EC50 | = | 5.012 | nM | 8.30 |