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Compound Detail

CHEMBL1814277

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O=c1cc[nH]c(=O)n1-c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1

Basic Information

ChEMBL ID CHEMBL1814277
Phase Preclinical
Structure Type MOL
InChI Key SCMBTOKLELJQBE-MHZLTWQESA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

525.6
MW (Da)
2.95
ALogP
8
HBA
5
HBD
136.8
PSA (Ų)
0.17
QED
1
Ro5 Violations
17
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C29H39N3O6
MW 525.65
Aromatic Rings 3
Heavy Atoms 38
NP-Likeness -0.06

Activity Summary

EC50 3 meas. best 9.1

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-2 adrenergic receptor
CHEMBL210
EC50 9.1 9.1 0.8 1
Beta-1 adrenergic receptor
CHEMBL213
EC50 6.6 6.6 251.2 1
Beta-3 adrenergic receptor
CHEMBL246
EC50 6.4 6.4 398.1 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
21696967 10.1016/j.bmc.2011.05.064 Beta-2 adrenergic receptor 2
21696967 10.1016/j.bmc.2011.05.064 Beta-1 adrenergic receptor 1
21696967 10.1016/j.bmc.2011.05.064 Beta-3 adrenergic receptor 1
21696967 10.1016/j.bmc.2011.05.064 Liver microsomes 1

Data from ChEMBL 36 via Core Engine