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Compound Detail

CHEMBL1814276

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CC(=O)O.NC(=O)CN1C(=O)CN(c2cccc(CCCCOCCCCCCNC[C@H](O)c3ccc(O)c(CO)c3)c2)C1=O

Basic Information

ChEMBL ID CHEMBL1814276
Phase Preclinical
Structure Type MOL
InChI Key XDGCBYWWQLLSJP-YCBFMBTMSA-N
Parent Compound CHEMBL1851624
Active Moiety CHEMBL1851624
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

570.7
MW (Da)
2.36
ALogP
8
HBA
5
HBD
165.7
PSA (Ų)
0.13
QED
1
Ro5 Violations
19
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C32H46N4O9
MW 630.74
Aromatic Rings 2
Heavy Atoms 41
NP-Likeness -0.44

Activity Summary

EC50 3 meas. best 9.6

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-2 adrenergic receptor
CHEMBL210
EC50 9.6 9.6 0.3 1
Beta-3 adrenergic receptor
CHEMBL246
EC50 7.1 7.1 79.4 1
Beta-1 adrenergic receptor
CHEMBL213
EC50 6.8 6.8 158.5 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
21696967 10.1016/j.bmc.2011.05.064 Beta-2 adrenergic receptor 2
21696967 10.1016/j.bmc.2011.05.064 Beta-1 adrenergic receptor 1
21696967 10.1016/j.bmc.2011.05.064 Beta-3 adrenergic receptor 1
21696967 10.1016/j.bmc.2011.05.064 Liver microsomes 1

Data from ChEMBL 36 via Core Engine