Assay Detail
Binding
CHEMBL652255
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In vitro blocking activity against beta adrenergic receptor, isolated from guinea pig atria
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Salicylamide derivatives related to medroxalol with alpha- and beta-adrenergic antagonist and antihypertension activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 39 | 6.27 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1671 | PROPRANOLOL HYDROCHLORIDE | 4.0 | 1 | 8.89 |
| CHEMBL1203105 | — | — | 1 | 8.46 |
| CHEMBL1203099 | — | — | 1 | 8.10 |
| CHEMBL1203104 | MEDROXALOL HYDROCHLORIDE | -1.0 | 1 | 7.82 |
| CHEMBL1203122 | — | — | 1 | 7.62 |
| CHEMBL1203101 | — | — | 1 | 7.21 |
| CHEMBL1203097 | — | — | 1 | 7.15 |
| CHEMBL1203115 | — | — | 1 | 6.90 |
| CHEMBL1203123 | — | — | 1 | 6.79 |
| CHEMBL1203110 | — | — | 1 | 6.70 |
| CHEMBL1203109 | — | — | 1 | 6.69 |
| CHEMBL1203098 | — | — | 1 | 6.55 |
| CHEMBL1203140 | — | — | 1 | 6.44 |
| CHEMBL1203108 | — | — | 1 | 6.41 |
| CHEMBL1203120 | — | — | 1 | 6.36 |
| CHEMBL1203124 | — | — | 1 | 6.33 |
| CHEMBL326283 | — | — | 1 | 6.17 |
| CHEMBL323702 | — | — | 1 | 6.14 |
| CHEMBL112157 | — | — | 1 | 5.97 |
| CHEMBL1203102 | — | — | 1 | 5.92 |
| CHEMBL1203100 | — | — | 1 | 5.88 |
| CHEMBL1203113 | — | — | 1 | 5.88 |
| CHEMBL1203138 | — | — | 1 | 5.84 |
| CHEMBL114349 | — | — | 1 | 5.84 |
| CHEMBL1203117 | — | — | 1 | 5.71 |
| CHEMBL1203116 | — | — | 1 | 5.45 |
| CHEMBL1203148 | — | — | 1 | 5.41 |
| CHEMBL1203112 | — | — | 1 | 5.37 |
| CHEMBL1203126 | — | — | 1 | 5.27 |
| CHEMBL1203111 | — | — | 1 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1671 | PROPRANOLOL HYDROCHLORIDE | Kd | = | 1.288 | nM | 8.89 |
| CHEMBL1203105 | — | Kd | = | 3.467 | nM | 8.46 |
| CHEMBL1203099 | — | Kd | = | 7.943 | nM | 8.10 |
| CHEMBL1203104 | MEDROXALOL HYDROCHLORIDE | Kd | = | 15.14 | nM | 7.82 |
| CHEMBL1203122 | — | Kd | = | 23.99 | nM | 7.62 |
| CHEMBL1203101 | — | Kd | = | 61.66 | nM | 7.21 |
| CHEMBL1203097 | — | Kd | = | 70.79 | nM | 7.15 |
| CHEMBL1203115 | — | Kd | = | 125.89 | nM | 6.90 |
| CHEMBL1203123 | — | Kd | = | 162.18 | nM | 6.79 |
| CHEMBL1203110 | — | Kd | = | 199.53 | nM | 6.70 |
| CHEMBL1203109 | — | Kd | = | 204.17 | nM | 6.69 |
| CHEMBL1203098 | — | Kd | = | 281.84 | nM | 6.55 |
| CHEMBL1203140 | — | Kd | = | 363.08 | nM | 6.44 |
| CHEMBL1203108 | — | Kd | = | 389.05 | nM | 6.41 |
| CHEMBL1203120 | — | Kd | = | 436.52 | nM | 6.36 |
| CHEMBL1203124 | — | Kd | = | 467.74 | nM | 6.33 |
| CHEMBL326283 | — | Kd | = | 676.08 | nM | 6.17 |
| CHEMBL323702 | — | Kd | = | 724.44 | nM | 6.14 |
| CHEMBL112157 | — | Kd | = | 1071.52 | nM | 5.97 |
| CHEMBL1203102 | — | Kd | = | 1202.26 | nM | 5.92 |
| CHEMBL1203113 | — | Kd | = | 1318.26 | nM | 5.88 |
| CHEMBL1203100 | — | Kd | = | 1318.26 | nM | 5.88 |
| CHEMBL1203138 | — | Kd | = | 1445.44 | nM | 5.84 |
| CHEMBL114349 | — | Kd | = | 1445.44 | nM | 5.84 |
| CHEMBL1203117 | — | Kd | = | 1949.84 | nM | 5.71 |
| CHEMBL1203116 | — | Kd | = | 3548.13 | nM | 5.45 |
| CHEMBL1203148 | — | Kd | = | 3890.45 | nM | 5.41 |
| CHEMBL1203112 | — | Kd | = | 4265.8 | nM | 5.37 |
| CHEMBL1203126 | — | Kd | = | 5370.32 | nM | 5.27 |
| CHEMBL1203111 | — | Kd | = | 6760.83 | nM | 5.17 |
| CHEMBL1203107 | — | Kd | = | 7943.28 | nM | 5.10 |
| CHEMBL1203114 | — | Kd | = | 8511.38 | nM | 5.07 |
| CHEMBL1203103 | — | Kd | = | 29512.09 | nM | 4.53 |
| CHEMBL1203139 | — | Kd | = | 64565.42 | nM | 4.19 |
| CHEMBL1203106 | — | Kd | > | 10000.0 | nM | - |
| CHEMBL1203125 | — | Kd | > | 10000.0 | nM | - |
| CHEMBL1204146 | PHENTOLAMINE HYDROCHLORIDE | Kd | > | 10000.0 | nM | - |
| CHEMBL116504 | — | Kd | > | 10000.0 | nM | - |
| CHEMBL1203118 | — | Kd | > | 4168.69 | nM | - |