Assay Detail
Functional
CHEMBL688166
Review assay metadata, readout intent, target linkage, and publication context from the same page.
spasmolytic activity in isolated guinea pig ileum preparation;- log KB; (Bacl2)
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Salicylamide derivatives related to medroxalol with alpha- and beta-adrenergic antagonist and antihypertension activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 40 | 5.44 | 6.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1203100 | — | — | 1 | 6.90 |
| CHEMBL1203122 | — | — | 1 | 6.90 |
| CHEMBL1203124 | — | — | 1 | 6.65 |
| CHEMBL1203109 | — | — | 1 | 6.42 |
| CHEMBL1203113 | — | — | 1 | 6.38 |
| CHEMBL1203097 | — | — | 1 | 6.17 |
| CHEMBL1203123 | — | — | 1 | 6.06 |
| CHEMBL1203117 | — | — | 1 | 5.90 |
| CHEMBL1203120 | — | — | 1 | 5.76 |
| CHEMBL1671 | PROPRANOLOL HYDROCHLORIDE | 4.0 | 1 | 5.75 |
| CHEMBL1203115 | — | — | 1 | 5.74 |
| CHEMBL1203110 | — | — | 1 | 5.73 |
| CHEMBL1204146 | PHENTOLAMINE HYDROCHLORIDE | -1.0 | 1 | 5.70 |
| CHEMBL1203104 | MEDROXALOL HYDROCHLORIDE | -1.0 | 1 | 5.63 |
| CHEMBL1203098 | — | — | 1 | 5.58 |
| CHEMBL1203099 | — | — | 1 | 5.56 |
| CHEMBL1203102 | — | — | 1 | 5.39 |
| CHEMBL1204337 | NYLIDRIN HYDROCHLORIDE | -1.0 | 1 | 5.37 |
| CHEMBL112157 | — | — | 1 | 5.34 |
| CHEMBL1203118 | — | — | 1 | 5.16 |
| CHEMBL1203101 | — | — | 1 | 5.06 |
| CHEMBL1203119 | — | — | 1 | 5.02 |
| CHEMBL1203140 | — | — | 1 | 4.87 |
| CHEMBL1203111 | — | — | 1 | 4.82 |
| CHEMBL1203125 | — | — | 1 | 4.76 |
| CHEMBL1203126 | — | — | 1 | 4.67 |
| CHEMBL326283 | — | — | 1 | 4.58 |
| CHEMBL114349 | — | — | 1 | 4.57 |
| CHEMBL1203148 | — | — | 1 | 4.48 |
| CHEMBL1203108 | — | — | 1 | 4.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1203100 | — | Kd | = | 125.89 | nM | 6.90 |
| CHEMBL1203122 | — | Kd | = | 125.89 | nM | 6.90 |
| CHEMBL1203124 | — | Kd | = | 223.87 | nM | 6.65 |
| CHEMBL1203109 | — | Kd | = | 380.19 | nM | 6.42 |
| CHEMBL1203113 | — | Kd | = | 416.87 | nM | 6.38 |
| CHEMBL1203097 | — | Kd | = | 676.08 | nM | 6.17 |
| CHEMBL1203123 | — | Kd | = | 870.96 | nM | 6.06 |
| CHEMBL1203117 | — | Kd | = | 1258.93 | nM | 5.90 |
| CHEMBL1203120 | — | Kd | = | 1737.8 | nM | 5.76 |
| CHEMBL1671 | PROPRANOLOL HYDROCHLORIDE | Kd | = | 1778.28 | nM | 5.75 |
| CHEMBL1203115 | — | Kd | = | 1819.7 | nM | 5.74 |
| CHEMBL1203110 | — | Kd | = | 1862.09 | nM | 5.73 |
| CHEMBL1204146 | PHENTOLAMINE HYDROCHLORIDE | Kd | = | 1995.26 | nM | 5.70 |
| CHEMBL1203104 | MEDROXALOL HYDROCHLORIDE | Kd | = | 2344.23 | nM | 5.63 |
| CHEMBL1203098 | — | Kd | = | 2630.27 | nM | 5.58 |
| CHEMBL1203099 | — | Kd | = | 2754.23 | nM | 5.56 |
| CHEMBL1203102 | — | Kd | = | 4073.8 | nM | 5.39 |
| CHEMBL1204337 | NYLIDRIN HYDROCHLORIDE | Kd | = | 4265.8 | nM | 5.37 |
| CHEMBL112157 | — | Kd | = | 4570.88 | nM | 5.34 |
| CHEMBL1203118 | — | Kd | = | 6918.31 | nM | 5.16 |
| CHEMBL1203101 | — | Kd | = | 8709.64 | nM | 5.06 |
| CHEMBL1203119 | — | Kd | = | 9549.93 | nM | 5.02 |
| CHEMBL1203140 | — | Kd | = | 13489.63 | nM | 4.87 |
| CHEMBL1203111 | — | Kd | = | 15135.61 | nM | 4.82 |
| CHEMBL1203125 | — | Kd | = | 17378.01 | nM | 4.76 |
| CHEMBL1203126 | — | Kd | = | 21379.62 | nM | 4.67 |
| CHEMBL326283 | — | Kd | = | 26302.68 | nM | 4.58 |
| CHEMBL114349 | — | Kd | = | 26915.35 | nM | 4.57 |
| CHEMBL1203148 | — | Kd | = | 33113.11 | nM | 4.48 |
| CHEMBL1203108 | — | Kd | = | 34673.69 | nM | 4.46 |
| CHEMBL1203105 | — | Kd | = | 43651.58 | nM | 4.36 |
| CHEMBL1203106 | — | Kd | = | 64565.42 | nM | 4.19 |
| CHEMBL1203103 | — | Kd | < | 63095.73 | nM | - |
| CHEMBL323702 | — | Kd | > | 100000.0 | nM | - |
| CHEMBL1203112 | — | Kd | = | 125892.54 | nM | - |
| CHEMBL1203114 | — | Kd | > | 74131.02 | nM | - |
| CHEMBL1203107 | — | Kd | > | 100000.0 | nM | - |
| CHEMBL1203116 | — | Kd | > | 61659.5 | nM | - |
| CHEMBL116504 | — | Kd | > | 100000.0 | nM | - |
| CHEMBL1203138 | — | Kd | > | 52480.75 | nM | - |