Review anchor
Cavia porcellus
ORGANISM · Cavia porcellus
As of 2026-09-13
Evidence Snapshot
Cavia porcellus
CHEMBL369
ORGANISM
Cavia porcellus
Identity Layer
Cross-source identity
Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Cavia porcellus as ChEMBL target CHEMBL369. Disease framing currently uses the Open Targets-ready proxy contract.
ChEMBL target ID
CHEMBL369
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine
As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy
As of 2026-09-13
www.ebi.ac.uk
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Review-ready Target Rationale
Why Cavia porcellus matters
Cavia porcellus is reviewed as Cavia porcellus; the current evidence base includes 81 approved drugs, 9915 compounds, and 5947 assays, with lead potency reaching pChEMBL 10.7.
Protein context
Cavia porcellus
Cavia porcellus
Review this target as Cavia porcellus.
Protein source · UniProt accession via ChEMBL component mappingDisease context
Disease signal
Disease relevance is not yet populated for this evidence card.
This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
ChEMBL target recordActivity base
Portfolio and assay base
ChEMBL currently tracks 81 approved drugs, 9915 compounds, and 5947 assays for this target. The dominant activity type is IC50. CHEMBL415247 is the current potency anchor at pChEMBL 10.7.
Use CHEMBL415247 as the tractability anchor when discussing potency (pChEMBL 10.7).
Activity source · ChEMBL 36 via Core Engine
81 approved
pChEMBL 10.7
Source Guidance
Start with the right source
Pick the first block or linked source that matches the review question in front of you.
Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution
Start with the review rationale when you need to explain why Cavia porcellus matters before drilling into raw source blocks.
Jump to Review RationaleNeed stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping
Go back to the target snapshot when you need the naming and mapping contract, not just the summarized rationale.
Open Protein ContextNeed disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy
Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.
Open Disease ContextSnapshot State
No project snapshot selected. Export uses the live evidence card state.
9915
Total Compounds
5947
Total Assays
81
Approved Drugs
IC50: 2217.0, KI: 49.0, EC50: 1344.0, KD: 572.0
Activity Types
pChEMBL Activity Distribution
Top 5 Inhibitors (by pChEMBL)
| Structure | Compound | pChEMBL | Type | Phase |
|---|---|---|---|---|
|
|
No preferred name
CHEMBL415247
|
10.7 | Ki | — |
|
|
No preferred name
CHEMBL88815
|
10.5 | IC50 | — |
|
|
No preferred name
CHEMBL573214
|
10.4 | Ki | — |
|
|
No preferred name
CHEMBL287868
|
10.4 | Kd | — |
|
|
No preferred name
CHEMBL320611
|
10.4 | Kd | — |
Approved Drugs
| Structure | Compound | First Approval |
|---|---|---|
|
|
CAPSAICIN
CHEMBL294199
|
2009 |
|
|
ICATIBANT
CHEMBL2028850
|
2008 |
|
|
RIMONABANT
CHEMBL111
|
2006 |
|
|
RUPATADINE
CHEMBL91397
|
2001 |
|
|
KETOTIFEN
CHEMBL534
|
1999 |
|
|
MONTELUKAST
CHEMBL787
|
1998 |
|
|
AZELASTINE
CHEMBL639
|
1996 |
|
|
REMIFENTANIL
CHEMBL1005
|
1996 |
|
|
ZAFIRLUKAST
CHEMBL603
|
1996 |
|
|
SERATRODAST
CHEMBL70972
|
1995 |
|
|
CETIRIZINE
CHEMBL1000
|
1995 |
|
|
LORATADINE
CHEMBL998
|
1993 |
|
|
GRANISETRON
CHEMBL289469
|
1993 |
|
|
CISAPRIDE
CHEMBL1729
|
1993 |
|
|
FELODIPINE
CHEMBL1480
|
1991 |
|
|
ONDANSETRON
CHEMBL46
|
1991 |
|
|
NIMODIPINE
CHEMBL1428
|
1988 |
|
|
ALFENTANIL
CHEMBL634
|
1986 |
|
|
TERFENADINE
CHEMBL17157
|
1985 |
|
|
GLYBURIDE
CHEMBL472
|
1984 |
|
|
MORPHINE
CHEMBL70
|
1984 |
|
|
NALTREXONE
CHEMBL19019
|
1984 |
|
|
SUFENTANIL
CHEMBL658
|
1984 |
|
|
DILTIAZEM HYDROCHLORIDE
CHEMBL1697
|
1982 |
|
|
SARALASIN
CHEMBL938
|
1982 |
|
|
DILTIAZEM
CHEMBL23
|
1982 |
|
|
NIFEDIPINE
CHEMBL193
|
1981 |
|
|
BUPRENORPHINE
CHEMBL511142
|
1981 |
|
|
ALBUTEROL
CHEMBL714
|
1981 |
|
|
VERAPAMIL
CHEMBL6966
|
1981 |
|
|
DOBUTAMINE
CHEMBL926
|
1978 |
|
|
DISOPYRAMIDE
CHEMBL517
|
1977 |
|
|
LOPERAMIDE
CHEMBL841
|
1976 |
|
|
SINCALIDE
CHEMBL1121
|
1976 |
|
|
DIGOXIN
CHEMBL1751
|
1975 |
|
|
PYRILAMINE
CHEMBL511
|
1973 |
|
|
PYRILAMINE MALEATE
CHEMBL1201006
|
1973 |
|
|
CARBACHOL
CHEMBL14
|
1972 |
|
|
FENTANYL
CHEMBL596
|
1968 |
|
|
PROPRANOLOL
CHEMBL27
|
1967 |
|
|
EPINEPHRINE
CHEMBL679
|
1965 |
|
|
ATROPINE
CHEMBL517712
|
1960 |
|
|
ATROPINE SULFATE
CHEMBL2146146
|
1960 |
|
|
OXYMORPHONE
CHEMBL963
|
1959 |
|
|
ISOPROTERENOL
CHEMBL434
|
1956 |
|
|
QUINIDINE
CHEMBL1294
|
1950 |
|
|
HISTAMINE
CHEMBL90
|
1939 |
Source Header