Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL2146146

ATROPINE SULFATE
💊 Approved Drug
Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
💊 Approved Drug
CN1[C@@H]2CC[C@H]1C[C@@H](OC(=O)C(CO)c1ccccc1)C2.O=S(=O)(O)O
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL2146146
Name ATROPINE SULFATE
Phase Approved
Structure Type MOL
InChI Key VJFQPODMEGSXHC-RIMUKSHESA-N
Therapeutic ✓ Yes
Parent Compound CHEMBL517712
Active Moiety CHEMBL517712

Known Names

Atropine sulfate Atropine sulfate anhydrous Atropine sulfate ansyr plastic syringe Atropine sulfate component of colonaid Atropine sulfate component of di-atro Atropine sulfate component of enlon-plus Atropine sulfate component of lo-trol Atropine sulfate component of logen Atropine sulfate component of lomanate Atropine sulfate component of lomotil Atropine sulfate component of lonox Atropine sulfate component of low-quel +12 more
3
Targets
5
Activities
2
Assay Types
0
PK Parameters
20
Publications
24
Known Names
8
Indications
3
Mechanisms

Molecular Properties

289.4
MW (Da)
1.93
ALogP
4
HBA
1
HBD
49.8
PSA (Ų)
0.86
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
First Approval 1960
Availability Prescription
Chirality Racemic

Routes of Administration

Oral Parenteral Topical
USAN Stem -trop-

Extended Properties

Molecular Formula C17H25NO7S
MW 387.45
Aromatic Rings 1
Heavy Atoms 21
NP-Likeness 0.79

Mechanism of Action

Mechanism Action Type Target Direct Efficacy
Muscarinic acetylcholine receptor M3 antagonist ANTAGONIST Muscarinic acetylcholine receptor M3 ✓ ✓
Muscarinic acetylcholine receptor M1 antagonist ANTAGONIST Muscarinic acetylcholine receptor M1 ✓ ✓
Muscarinic acetylcholine receptor M2 antagonist ANTAGONIST Muscarinic acetylcholine receptor M2 ✓ ✓

Indications

Mydriasis Parkinson Disease Peptic Ulcer Rhinitis, Allergic, Seasonal Rhinitis, Allergic, Seasonal Myopia Organophosphate Poisoning Postoperative Complications

Activity Summary

Kd 3 meas. best 9.31
IC50 2 meas. best 5.3

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
 Kd 9.31 9.31 0.5 1
Cavia porcellus
CHEMBL369
 Kd 9.06 7.64 0.9 2
Plasmodium falciparum
CHEMBL364
 IC50 5.3 5.15 5011.9 2

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Unchecked Kd = 0.49 nM 9.31 Antagonist activity at muscarinic acetylcholine receptor in guinea pig ileum ass... 423178
Cavia porcellus Kd = 0.871 nM 9.06 In vitro anticholinergic activity was determined by acetylcholine induced contra... 6102153
Cavia porcellus Kd = 602.56 nM 6.22 In vitro antihistaminic activity was determined by histamine induced contraction... 6102153
Plasmodium falciparum IC50 = 5011.87 nM 5.3 Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR gr... 19734910
Plasmodium falciparum IC50 = 10000.0 nM 5.0 Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR g... 19734910

Literature References

PubMed DOI Target Context # Activities
533877 10.1021/jm00197a006 Mus musculus 3
6126589 10.1021/jm00350a018 Rattus norvegicus 3
6195312 10.1021/np50028a027 Enterococcus faecalis 2
- 10.6019/CHEMBL4495565 SARS-CoV-2 2
- 10.6019/CHEMBL4808148 Histone deacetylase 6 2
19734910 10.1038/nchembio.215 Plasmodium falciparum 2
6195312 10.1021/np50028a027 Saccharomyces cerevisiae 2
6195312 10.1021/np50028a027 Candida albicans 2
6195312 10.1021/np50028a027 Staphylococcus aureus 2
6195312 10.1021/np50028a027 Pseudomonas fluorescens 2
6195312 10.1021/np50028a027 Pseudomonas aeruginosa 2
6195312 10.1021/np50028a027 Escherichia coli 2
6102153 10.1021/jm00176a009 Cavia porcellus 2
7143364 10.1021/jm00352a029 Cavia porcellus 2
6195312 10.1021/np50028a027 Bacillus subtilis 1
3941416 10.1021/jm00151a002 Mus musculus 1
20022146 10.1016/j.ejmech.2009.11.034 Homo sapiens 1
7143364 10.1021/jm00352a029 Mus musculus 1
23062825 10.1016/j.bmc.2012.09.040 Acetylcholinesterase 1
23062825 10.1016/j.bmc.2012.09.040 Cholinesterase 1

Data from ChEMBL 36 via Core Engine