Assay Detail
Functional
CHEMBL689680
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In vitro antihistaminic activity was determined by histamine induced contraction of guinea pig ileum
9
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and psychoanaleptic properties of new compounds structurally related to diphenhydramine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 9 | 6.76 | 9.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1201006 | PYRILAMINE MALEATE | 4.0 | 1 | 9.38 |
| CHEMBL1743876 | — | — | 1 | 8.14 |
| CHEMBL1743871 | — | — | 2 | 7.25 |
| CHEMBL1744366 | — | — | 1 | 6.65 |
| CHEMBL2146146 | ATROPINE SULFATE | 4.0 | 1 | 6.22 |
| CHEMBL289043 | — | — | 1 | 6.12 |
| CHEMBL1744371 | — | — | 1 | 5.45 |
| CHEMBL501 | AMPHETAMINE SULFATE | 4.0 | 1 | 4.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1201006 | PYRILAMINE MALEATE | Kd | = | 0.4169 | nM | 9.38 |
| CHEMBL1743876 | — | Kd | = | 7.244 | nM | 8.14 |
| CHEMBL1743871 | — | Kd | = | 56.23 | nM | 7.25 |
| CHEMBL1743871 | — | Kd | = | 165.96 | nM | 6.78 |
| CHEMBL1744366 | — | Kd | = | 223.87 | nM | 6.65 |
| CHEMBL2146146 | ATROPINE SULFATE | Kd | = | 602.56 | nM | 6.22 |
| CHEMBL289043 | — | Kd | = | 758.58 | nM | 6.12 |
| CHEMBL1744371 | — | Kd | = | 3548.13 | nM | 5.45 |
| CHEMBL501 | AMPHETAMINE SULFATE | Kd | = | 13489.63 | nM | 4.87 |