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Compound Detail

CHEMBL501

AMPHETAMINE SULFATE
💊 Approved Drug
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💊 Approved Drug
CC(N)Cc1ccccc1.O=S(=O)(O)O
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL501
Name AMPHETAMINE SULFATE
Phase Approved
Structure Type MOL
InChI Key SOFQDLYSFOWTJX-UHFFFAOYSA-N
Therapeutic ✓ Yes
Parent Compound CHEMBL405
Active Moiety CHEMBL405

Known Names

Amfetamine sulfate Amfetamine sulphate Amphetamine sulfate Amphetamine sulfate component of delcobese Amphetamine sulfate component of mydayis Astedin Benzedrine Dl-amphetamine sulfate Dl-amphetamine sulphate Evekeo Evekeo odt NSC-170999
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
9
Publications
12
Known Names
4
Indications
2
Mechanisms

Molecular Properties

135.2
MW (Da)
1.58
ALogP
1
HBA
1
HBD
26.0
PSA (Ų)
0.65
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
First Approval 1960
Availability Prescription
Chirality Racemic

Routes of Administration

Oral

Flags

Black Box Warning

Extended Properties

Molecular Formula C9H15NO4S
MW 233.29
Aromatic Rings 1
Heavy Atoms 10
NP-Likeness -0.02

Mechanism of Action

Mechanism Action Type Target Direct Efficacy
Dopamine transporter releasing agent RELEASING AGENT Sodium-dependent dopamine transporter ✓ ✓
Norepinephrine transporter releasing agent RELEASING AGENT Sodium-dependent noradrenaline transporter ✓ ✓

Indications

Attention Deficit Disorder with Hyperactivity Narcolepsy Obesity Cocaine-Related Disorders

Drug Warnings

Black Box Warning
cardiotoxicity
Country: United States
Black Box Warning
misuse
Country: United States
Black Box Warning
neurotoxicity
Country: United States

Activity Summary

Kd 1 meas. best 4.87
Ki 1 meas. best 4.91

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Amine oxidase [flavin-containing] A
CHEMBL3358
 Ki 4.91 4.91 12200.0 1
Cavia porcellus
CHEMBL369
 Kd 4.87 4.87 13489.6 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Amine oxidase [flavin-containing] A Ki = 12200.0 nM 4.91 Inhibition of MAOA in rat brain mitochondria 19243954
Cavia porcellus Kd = 13489.63 nM 4.87 In vitro antihistaminic activity was determined by histamine induced contraction... 6102153

Literature References

PubMed DOI Target Context # Activities
8097538 10.1021/jm00060a015 Mus musculus 3
6102153 10.1021/jm00176a009 Mus musculus 2
6102153 10.1021/jm00176a009 Canis familiaris 2
6102153 10.1021/jm00176a009 Cavia porcellus 2
5607 10.1021/jm00227a010 Mus musculus 2
6102153 10.1021/jm00176a009 Rattus norvegicus 1
2374150 10.1021/jm00170a031 Rattus norvegicus 1
19243954 10.1016/j.bmc.2009.01.074 Amine oxidase [flavin-containing] A 1
19243954 10.1016/j.bmc.2009.01.074 Amine oxidase [flavin-containing] B 1

Data from ChEMBL 36 via Core Engine