Assay Detail
Binding
CHEMBL1022171
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Inhibition of MAOA in rat brain mitochondria
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Mitochondria |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Amine oxidase [flavin-containing] A (CHEMBL3358) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 5.90 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL455991 | — | — | 1 | 6.89 |
| CHEMBL443427 | — | — | 1 | 6.75 |
| CHEMBL161985 | — | — | 1 | 6.66 |
| CHEMBL6467 | 4-METHYLTHIOAMPHETAMINE | — | 1 | 6.60 |
| CHEMBL278663 | PARA-METHOXYAMPHETAMINE | — | 1 | 6.60 |
| CHEMBL456012 | — | — | 1 | 6.50 |
| CHEMBL471839 | — | — | 1 | 6.38 |
| CHEMBL450964 | — | — | 1 | 6.35 |
| CHEMBL455558 | — | — | 1 | 6.30 |
| CHEMBL471840 | — | — | 1 | 6.17 |
| CHEMBL447882 | — | — | 1 | 5.82 |
| CHEMBL456013 | — | — | 1 | 5.47 |
| CHEMBL456006 | — | — | 1 | 5.42 |
| CHEMBL471838 | — | — | 1 | 5.25 |
| CHEMBL510214 | — | — | 1 | 5.16 |
| CHEMBL501 | AMPHETAMINE SULFATE | 4.0 | 1 | 4.91 |
| CHEMBL456005 | — | — | 1 | 4.84 |
| CHEMBL457038 | — | — | 1 | 4.05 |
| CHEMBL457039 | — | — | 1 | - |
| CHEMBL456841 | — | — | 1 | - |
| CHEMBL456842 | — | — | 1 | - |
| CHEMBL469310 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL455991 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL443427 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL161985 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL6467 | 4-METHYLTHIOAMPHETAMINE | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL278663 | PARA-METHOXYAMPHETAMINE | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL456012 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL471839 | — | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL450964 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL455558 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL471840 | — | Ki | = | 680.0 | nM | 6.17 |
| CHEMBL447882 | — | Ki | = | 1530.0 | nM | 5.82 |
| CHEMBL456013 | — | Ki | = | 3420.0 | nM | 5.47 |
| CHEMBL456006 | — | Ki | = | 3780.0 | nM | 5.42 |
| CHEMBL471838 | — | Ki | = | 5630.0 | nM | 5.25 |
| CHEMBL510214 | — | Ki | = | 6930.0 | nM | 5.16 |
| CHEMBL501 | AMPHETAMINE SULFATE | Ki | = | 12200.0 | nM | 4.91 |
| CHEMBL456005 | — | Ki | = | 14500.0 | nM | 4.84 |
| CHEMBL457038 | — | Ki | = | 90000.0 | nM | 4.05 |
| CHEMBL457039 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL456841 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL456842 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL469310 | — | Ki | > | 100000.0 | nM | - |