Assay Detail
Functional
CHEMBL689679
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro anticholinergic activity was determined by acetylcholine induced contraction of guinea pig ileum
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and psychoanaleptic properties of new compounds structurally related to diphenhydramine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 7 | 6.36 | 9.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2146146 | ATROPINE SULFATE | 4.0 | 1 | 9.06 |
| CHEMBL1743876 | — | — | 1 | 6.51 |
| CHEMBL1744371 | — | — | 1 | 5.71 |
| CHEMBL1201006 | PYRILAMINE MALEATE | 4.0 | 1 | 5.40 |
| CHEMBL1744366 | — | — | 1 | 5.14 |
| CHEMBL501 | AMPHETAMINE SULFATE | 4.0 | 1 | - |
| CHEMBL289043 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2146146 | ATROPINE SULFATE | Kd | = | 0.871 | nM | 9.06 |
| CHEMBL1743876 | — | Kd | = | 309.03 | nM | 6.51 |
| CHEMBL1744371 | — | Kd | = | 1949.84 | nM | 5.71 |
| CHEMBL1201006 | PYRILAMINE MALEATE | Kd | = | 3981.07 | nM | 5.40 |
| CHEMBL1744366 | — | Kd | = | 7244.36 | nM | 5.14 |
| CHEMBL501 | AMPHETAMINE SULFATE | Kd | > | 1000000.0 | nM | - |
| CHEMBL289043 | — | Kd | = | 114815.36 | nM | - |