Compound Detail
CHEMBL1203119
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL1203119 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JZQXVEMEFSUMLU-UHFFFAOYSA-N |
| Parent Compound | CHEMBL324920 |
| Active Moiety | CHEMBL324920 |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
385.5
MW (Da)
1.62
ALogP
6
HBA
3
HBD
85.3
PSA (Ų)
0.70
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 2 meas. best 7.95
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Adrenergic receptor alpha-1 CHEMBL2094251 | Kd | 7.95 | 7.95 | 11.2 | 1 |
| Cavia porcellus CHEMBL369 | Kd | 5.02 | 5.02 | 9549.9 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Adrenergic receptor alpha-1 | Kd | = | 11.22 | nM | 7.95 | In vitro blocking activity against alpha adrenergic receptor, isolated from rabb... | 6115059 |
| Cavia porcellus | Kd | = | 9549.93 | nM | 5.02 | spasmolytic activity in isolated guinea pig ileum preparation;- log KB; (Bacl2) | 6115059 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 6115059 | 10.1021/jm00135a017 | Rattus norvegicus | 2 |
| 6115059 | 10.1021/jm00135a017 | Adrenergic receptor alpha-1 | 1 |
| 6115059 | 10.1021/jm00135a017 | Cavia porcellus | 1 |
Data from ChEMBL 36 via Core Engine