Assay Detail
Binding
CHEMBL642904
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In vitro blocking activity against alpha adrenergic receptor, isolated from rabbit aortic strip
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Salicylamide derivatives related to medroxalol with alpha- and beta-adrenergic antagonist and antihypertension activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 40 | 6.43 | 7.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1203119 | — | — | 1 | 7.95 |
| CHEMBL1204146 | PHENTOLAMINE HYDROCHLORIDE | -1.0 | 1 | 7.78 |
| CHEMBL1203110 | — | — | 1 | 7.57 |
| CHEMBL323702 | — | — | 1 | 7.56 |
| CHEMBL1203123 | — | — | 1 | 7.45 |
| CHEMBL1203140 | — | — | 1 | 7.42 |
| CHEMBL1203124 | — | — | 1 | 7.21 |
| CHEMBL1203139 | — | — | 1 | 7.04 |
| CHEMBL1203108 | — | — | 1 | 7.00 |
| CHEMBL1203117 | — | — | 1 | 6.94 |
| CHEMBL326283 | — | — | 1 | 6.87 |
| CHEMBL1203148 | — | — | 1 | 6.80 |
| CHEMBL1203116 | — | — | 1 | 6.70 |
| CHEMBL1203118 | — | — | 1 | 6.63 |
| CHEMBL1203106 | — | — | 1 | 6.54 |
| CHEMBL1203115 | — | — | 1 | 6.33 |
| CHEMBL1203126 | — | — | 1 | 6.27 |
| CHEMBL1204337 | NYLIDRIN HYDROCHLORIDE | -1.0 | 1 | 6.21 |
| CHEMBL1203102 | — | — | 1 | 6.21 |
| CHEMBL114349 | — | — | 1 | 6.20 |
| CHEMBL1203138 | — | — | 1 | 6.13 |
| CHEMBL1203112 | — | — | 1 | 6.08 |
| CHEMBL1203100 | — | — | 1 | 6.05 |
| CHEMBL112157 | — | — | 1 | 6.04 |
| CHEMBL1203109 | — | — | 1 | 5.90 |
| CHEMBL1203120 | — | — | 1 | 5.86 |
| CHEMBL1203113 | — | — | 1 | 5.85 |
| CHEMBL1203122 | — | — | 1 | 5.73 |
| CHEMBL1203099 | — | — | 1 | 5.56 |
| CHEMBL1203111 | — | — | 1 | 5.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1203119 | — | Kd | = | 11.22 | nM | 7.95 |
| CHEMBL1204146 | PHENTOLAMINE HYDROCHLORIDE | Kd | = | 16.6 | nM | 7.78 |
| CHEMBL1203110 | — | Kd | = | 26.92 | nM | 7.57 |
| CHEMBL323702 | — | Kd | = | 27.54 | nM | 7.56 |
| CHEMBL1203123 | — | Kd | = | 35.48 | nM | 7.45 |
| CHEMBL1203140 | — | Kd | = | 38.02 | nM | 7.42 |
| CHEMBL1203124 | — | Kd | = | 61.66 | nM | 7.21 |
| CHEMBL1203139 | — | Kd | = | 91.2 | nM | 7.04 |
| CHEMBL1203108 | — | Kd | = | 100.0 | nM | 7.00 |
| CHEMBL1203117 | — | Kd | = | 114.82 | nM | 6.94 |
| CHEMBL326283 | — | Kd | = | 134.9 | nM | 6.87 |
| CHEMBL1203148 | — | Kd | = | 158.49 | nM | 6.80 |
| CHEMBL1203116 | — | Kd | = | 199.53 | nM | 6.70 |
| CHEMBL1203118 | — | Kd | = | 234.42 | nM | 6.63 |
| CHEMBL1203106 | — | Kd | = | 288.4 | nM | 6.54 |
| CHEMBL1203115 | — | Kd | = | 467.74 | nM | 6.33 |
| CHEMBL1203126 | — | Kd | = | 537.03 | nM | 6.27 |
| CHEMBL1204337 | NYLIDRIN HYDROCHLORIDE | Kd | = | 616.6 | nM | 6.21 |
| CHEMBL1203102 | — | Kd | = | 616.6 | nM | 6.21 |
| CHEMBL114349 | — | Kd | = | 630.96 | nM | 6.20 |
| CHEMBL1203138 | — | Kd | = | 741.31 | nM | 6.13 |
| CHEMBL1203112 | — | Kd | = | 831.76 | nM | 6.08 |
| CHEMBL1203100 | — | Kd | = | 891.25 | nM | 6.05 |
| CHEMBL112157 | — | Kd | = | 912.01 | nM | 6.04 |
| CHEMBL1203109 | — | Kd | = | 1258.93 | nM | 5.90 |
| CHEMBL1203120 | — | Kd | = | 1380.38 | nM | 5.86 |
| CHEMBL1203113 | — | Kd | = | 1412.54 | nM | 5.85 |
| CHEMBL1203122 | — | Kd | = | 1862.09 | nM | 5.73 |
| CHEMBL1203099 | — | Kd | = | 2754.23 | nM | 5.56 |
| CHEMBL1203111 | — | Kd | = | 3388.44 | nM | 5.47 |
| CHEMBL1203101 | — | Kd | = | 3467.37 | nM | 5.46 |
| CHEMBL1203097 | — | Kd | = | 4897.79 | nM | 5.31 |
| CHEMBL1203107 | — | Kd | = | 6309.57 | nM | 5.20 |
| CHEMBL1203114 | — | Kd | = | 7413.1 | nM | 5.13 |
| CHEMBL1671 | PROPRANOLOL HYDROCHLORIDE | Kd | > | 10000.0 | nM | - |
| CHEMBL116504 | — | Kd | > | 10000.0 | nM | - |
| CHEMBL1203098 | — | Kd | > | 10000.0 | nM | - |
| CHEMBL1203105 | — | Kd | > | 7244.36 | nM | - |
| CHEMBL1203103 | — | Kd | > | 10000.0 | nM | - |
| CHEMBL1203125 | — | Kd | > | 10000.0 | nM | - |