Assay Detail
Binding
CHEMBL653458
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Affinity for cow beta-2 adrenergic receptor by measuring displacement (-)-[3H]dihydroalprenolol (DHA)
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Quantitative evaluation of the beta 2-adrenoceptor affinity of phenoxypropanolamines and phenylethanolamines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 34 | 6.56 | 9.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1159892 | PROCINOLOL | 2.0 | 1 | 9.41 |
| CHEMBL1159723 | — | — | 1 | 9.20 |
| CHEMBL1671 | PROPRANOLOL HYDROCHLORIDE | 4.0 | 1 | 9.05 |
| CHEMBL6920 | — | — | 1 | 7.99 |
| CHEMBL1159714 | — | — | 1 | 7.99 |
| CHEMBL1159889 | — | — | 1 | 7.75 |
| CHEMBL1159888 | — | — | 1 | 7.66 |
| CHEMBL49080 | CLENBUTEROL | 2.0 | 1 | 7.44 |
| CHEMBL67096 | TOLIPROLOL | 2.0 | 1 | 7.36 |
| CHEMBL1159891 | — | — | 1 | 7.30 |
| CHEMBL1159713 | — | — | 1 | 7.24 |
| CHEMBL1159717 | TULOBUTEROL | 2.0 | 1 | 6.89 |
| CHEMBL16476 | PRONETALOL | 4.0 | 1 | 6.80 |
| CHEMBL434 | ISOPROTERENOL | 4.0 | 1 | 6.48 |
| CHEMBL349845 | — | — | 1 | 6.33 |
| CHEMBL1159712 | — | — | 1 | 6.28 |
| CHEMBL714 | ALBUTEROL | 4.0 | 1 | 6.28 |
| CHEMBL471 | SOTALOL | 4.0 | 1 | 6.24 |
| CHEMBL1159715 | COLTEROL | 2.0 | 1 | 6.22 |
| CHEMBL327122 | METATEROL | 2.0 | 1 | 6.04 |
| CHEMBL1160714 | PRENALTEROL | 2.0 | 1 | 5.97 |
| CHEMBL1159887 | — | — | 1 | 5.90 |
| CHEMBL127349 | NIFENALOL | 2.0 | 1 | 5.88 |
| CHEMBL1159711 | — | — | 1 | 5.71 |
| CHEMBL1159710 | — | — | 1 | 5.69 |
| CHEMBL1159890 | — | — | 1 | 5.67 |
| CHEMBL321468 | — | — | 1 | 5.50 |
| CHEMBL1760 | TERBUTALINE | 4.0 | 1 | 5.40 |
| CHEMBL109378 | DETERENOL | 2.0 | 1 | 5.37 |
| CHEMBL1159719 | — | — | 1 | 5.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1159892 | PROCINOLOL | Kd | = | 0.39 | nM | 9.41 |
| CHEMBL1159723 | — | Kd | = | 0.63 | nM | 9.20 |
| CHEMBL1671 | PROPRANOLOL HYDROCHLORIDE | Kd | = | 0.89 | nM | 9.05 |
| CHEMBL6920 | — | Kd | = | 10.23 | nM | 7.99 |
| CHEMBL1159714 | — | Kd | = | 10.23 | nM | 7.99 |
| CHEMBL1159889 | — | Kd | = | 17.78 | nM | 7.75 |
| CHEMBL1159888 | — | Kd | = | 21.88 | nM | 7.66 |
| CHEMBL49080 | CLENBUTEROL | Kd | = | 36.0 | nM | 7.44 |
| CHEMBL67096 | TOLIPROLOL | Kd | = | 43.65 | nM | 7.36 |
| CHEMBL1159891 | — | Kd | = | 50.12 | nM | 7.30 |
| CHEMBL1159713 | — | Kd | = | 58.0 | nM | 7.24 |
| CHEMBL1159717 | TULOBUTEROL | Kd | = | 130.0 | nM | 6.89 |
| CHEMBL16476 | PRONETALOL | Kd | = | 160.0 | nM | 6.80 |
| CHEMBL434 | ISOPROTERENOL | Kd | = | 330.0 | nM | 6.48 |
| CHEMBL349845 | — | Kd | = | 470.0 | nM | 6.33 |
| CHEMBL1159712 | — | Kd | = | 520.0 | nM | 6.28 |
| CHEMBL714 | ALBUTEROL | Kd | = | 520.0 | nM | 6.28 |
| CHEMBL471 | SOTALOL | Kd | = | 580.0 | nM | 6.24 |
| CHEMBL1159715 | COLTEROL | Kd | = | 600.0 | nM | 6.22 |
| CHEMBL327122 | METATEROL | Kd | = | 910.0 | nM | 6.04 |
| CHEMBL1160714 | PRENALTEROL | Kd | = | 1072.0 | nM | 5.97 |
| CHEMBL1159887 | — | Kd | = | 1260.0 | nM | 5.90 |
| CHEMBL127349 | NIFENALOL | Kd | = | 1320.0 | nM | 5.88 |
| CHEMBL1159711 | — | Kd | = | 1950.0 | nM | 5.71 |
| CHEMBL1159710 | — | Kd | = | 2040.0 | nM | 5.69 |
| CHEMBL1159890 | — | Kd | = | 2140.0 | nM | 5.67 |
| CHEMBL321468 | — | Kd | = | 3160.0 | nM | 5.50 |
| CHEMBL1760 | TERBUTALINE | Kd | = | 3980.0 | nM | 5.40 |
| CHEMBL109378 | DETERENOL | Kd | = | 4270.0 | nM | 5.37 |
| CHEMBL1159719 | — | Kd | = | 5130.0 | nM | 5.29 |
| CHEMBL776 | METAPROTERENOL | Kd | = | 9120.0 | nM | 5.04 |
| CHEMBL6995 | PRACTOLOL | Kd | = | 20417.0 | nM | 4.69 |
| CHEMBL7154 | — | Kd | = | 53700.0 | nM | 4.27 |
| CHEMBL423 | BETAXOLOL | Kd | = | 186210.0 | nM | - |