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Compound Detail

CHEMBL349845

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CC(C)(C)NCC(O)c1ccc(O)c(C(N)=O)c1

Basic Information

ChEMBL ID CHEMBL349845
Phase Preclinical
Structure Type MOL
InChI Key XJSJWMNGCFMVJB-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

252.3
MW (Da)
0.91
ALogP
4
HBA
4
HBD
95.6
PSA (Ų)
0.64
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C13H20N2O3
MW 252.31
Aromatic Rings 1
Heavy Atoms 18
NP-Likeness -0.18

Activity Summary

Kd 1 meas. best 6.33

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-2 adrenergic receptor
CHEMBL3373
Kd 6.33 6.33 470.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
2870189 10.1021/jm00154a020 Beta-2 adrenergic receptor 4
2836587 10.1021/jm00401a004 Beta-2 adrenergic receptor 3
2993621 10.1021/jm00147a037 Beta-2 adrenergic receptor 2
2870189 10.1021/jm00154a020 ADMET 1
2870189 10.1021/jm00154a020 No relevant target 1

Data from ChEMBL 36 via Core Engine