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Compound Detail

CHEMBL127349

NIFENALOL
🧪 Phase II
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🧪 Phase II
CC(C)NCC(O)c1ccc([N+](=O)[O-])cc1

Basic Information

ChEMBL ID CHEMBL127349
Name NIFENALOL
Phase Phase II
Structure Type MOL
InChI Key UAORFCGRZIGNCI-UHFFFAOYSA-N

Known Names

DL-INPEA Nifenalol Racemic nifenalol
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
10
Publications
3
Known Names

Molecular Properties

224.3
MW (Da)
1.63
ALogP
4
HBA
2
HBD
75.4
PSA (Ų)
0.59
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Chirality Racemic
USAN Stem -alol

Extended Properties

Molecular Formula C11H16N2O3
MW 224.26
Aromatic Rings 1
Heavy Atoms 16
NP-Likeness -0.80

Activity Summary

Kd 2 meas. best 6.0

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
Kd 6.0 6.0 1000.0 1
Beta-2 adrenergic receptor
CHEMBL3373
Kd 5.88 5.88 1320.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
2993621 10.1021/jm00147a037 Beta-2 adrenergic receptor 2
2836587 10.1021/jm00401a004 Beta-2 adrenergic receptor 2
- 10.6019/CHEMBL4495565 SARS-CoV-2 2
- 10.6019/CHEMBL4808148 Histone deacetylase 6 2
- 10.1016/S0960-894X(97)00046-2 Adrenergic receptor beta 1
2579237 10.1021/jm00381a019 Sodium channel alpha subunits; brain (Types I, II, III) 1
21413808 10.1021/jm1013693 Unchecked 1
- 10.21203/rs.3.rs-23951/v1 SARS-CoV-2 1
- 10.1101/2020.04.21.054387 SARS-CoV-2 1
- 10.6019/CHEMBL4495564 Replicase polyprotein 1ab 1

Data from ChEMBL 36 via Core Engine