Compound Detail
CHEMBL1760
TERBUTALINE 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL1760 |
| Name | TERBUTALINE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | XWTYSIMOBUGWOL-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
2
Targets
4
Activities
2
Assay Types
15
PK Parameters
20
Publications
4
Known Names
6
Indications
Molecular Properties
225.3
MW (Da)
1.52
ALogP
4
HBA
4
HBD
72.7
PSA (Ų)
0.63
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1974 |
| Availability | Prescription |
| Chirality | Racemic |
Indications
Lung Diseases, Obstructive Asthma Pulmonary Disease, Chronic Obstructive Neuralgia Purpura, Thrombocytopenic, Idiopathic Diabetes Mellitus, Type 1
ATC Classification
R03AC03
terbutaline
Level 1: RESPIRATORY SYSTEM
Level 2: DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
R03CC03
terbutaline
Level 1: RESPIRATORY SYSTEM
Level 2: DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
R03CC53
terbutaline, combinations
Level 1: RESPIRATORY SYSTEM
Level 2: DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
Activity Summary
Kd 3 meas. best 5.6
EC50 1 meas. best 5.5
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Beta-2 adrenergic receptor CHEMBL210 | Kd | 5.6 | 5.6 | 2510.0 | 2 |
| Beta-2 adrenergic receptor CHEMBL210 | EC50 | 5.5 | 5.5 | 3162.3 | 1 |
| Beta-2 adrenergic receptor CHEMBL3373 | Kd | 5.4 | 5.4 | 3980.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 3.1 | mL.min-1.kg-1 | Homo sapiens |
| CL | 3.4 | mL.min-1.kg-1 | Homo sapiens |
| CL | 1.2 | mL.min-1.kg-1 | Homo sapiens |
| CL | 3.4 | mL.min-1.kg-1 | Homo sapiens |
| CL | 3.4 | mL.min-1.kg-1 | Homo sapiens |
| F | 20.0 | % | Homo sapiens |
| F | 14.0 | % | Homo sapiens |
| F | 14.0 | % | Homo sapiens |
| Fu | 0.8 | - | - |
| Fu | 0.187 | - | - |
| Fu | 0.8 | - | Homo sapiens |
| Fu | 0.75 | - | Homo sapiens |
| Fu | 0.75 | - | Homo sapiens |
| MRT | 7.4 | hr | Homo sapiens |
| T1/2 | 15.0 | hr | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Beta-2 adrenergic receptor | Kd | = | 2510.0 | nM | 5.6 | Binding affinity to human adrenergic beta2 receptor | 19168263 |
| Beta-2 adrenergic receptor | Kd | = | 2511.89 | nM | 5.6 | Binding affinity to beta-2 adrenergic receptor (unknown origin) at 1 to 10000 nM | 23954364 |
| Beta-2 adrenergic receptor | EC50 | = | 3162.28 | nM | 5.5 | Agonist activity at human adrenergic beta2 receptor expressed in H292 cells asse... | 21652207 |
| Beta-2 adrenergic receptor | Kd | = | 3980.0 | nM | 5.4 | Affinity for cow beta-2 adrenergic receptor by measuring displacement (-)-[3H]di... | 2993621 |
Literature References
Data from ChEMBL 36 via Core Engine