Assay Detail
Binding
CHEMBL1058735
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Binding affinity to human adrenergic beta2 receptor
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis, pharmacological and in silico evaluation of 1-(4-di-hydroxy-3,5-dioxa-4-borabicyclo[4.4.0]deca-7,9,11-trien-9-yl)-2-(tert-butylamino)ethanol, a compound designed to act as a beta2 adrenoceptor agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 8 | 6.54 | 9.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL513389 | ZENIDOLOL | 2.0 | 1 | 9.20 |
| CHEMBL27 | PROPRANOLOL | 4.0 | 1 | 9.10 |
| CHEMBL434 | ISOPROTERENOL | 4.0 | 1 | 7.30 |
| CHEMBL679 | EPINEPHRINE | 4.0 | 1 | 6.20 |
| CHEMBL1760 | TERBUTALINE | 4.0 | 1 | 5.60 |
| CHEMBL1437 | NOREPINEPHRINE | 4.0 | 1 | 5.40 |
| CHEMBL776 | METAPROTERENOL | 4.0 | 1 | 5.32 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 4.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL513389 | ZENIDOLOL | Kd | = | 0.63 | nM | 9.20 |
| CHEMBL27 | PROPRANOLOL | Kd | = | 0.79 | nM | 9.10 |
| CHEMBL434 | ISOPROTERENOL | Kd | = | 50.0 | nM | 7.30 |
| CHEMBL679 | EPINEPHRINE | Kd | = | 630.0 | nM | 6.20 |
| CHEMBL1760 | TERBUTALINE | Kd | = | 2510.0 | nM | 5.60 |
| CHEMBL1437 | NOREPINEPHRINE | Kd | = | 3980.0 | nM | 5.40 |
| CHEMBL776 | METAPROTERENOL | Kd | = | 4810.0 | nM | 5.32 |
| CHEMBL59 | DOPAMINE | Kd | = | 64560.0 | nM | 4.19 |