Insulin-degrading enzyme · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P14735. Use UniProt P14735 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P14735 as the stable identity anchor, then attach disease evidence before program review.
Insulin-degrading enzyme
Review this target as Insulin-degrading enzyme, mapped to UniProt P14735. Sequence length is 1019 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Insulin-degrading enzyme as ChEMBL target CHEMBL1293287, mapped to UniProt P14735. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Insulin-degrading enzyme is the right protein anchor across sources, using UniProt P14735 as the stable mapping.
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| Preferred Name | Insulin-degrading enzyme |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P14735 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Insulin-degrading enzyme |
| UniProt Accession | P14735 |
| Component Type | Protein |
| Sequence Length | 1019 aa |
Insulin-degrading enzyme
Review this target as Insulin-degrading enzyme, mapped to UniProt P14735. Sequence length is 1019 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL2324206 | 8.85 | Ki | 1.4 | Preclinical |
| CHEMBL2324220 | 8.77 | Ki | 1.7 | Preclinical |
| CHEMBL4437643 | 8.4 | IC50 | 4.0 | Preclinical |
| CHEMBL51085 | 7.85 | IC50 | 14.0 | Clinical |
| CHEMBL4211248 | 7.66 | Kd | 22.0 | Preclinical |
| CHEMBL2324207 | 7.64 | Ki | 23.1 | Preclinical |
| CHEMBL2324201 | 7.59 | Ki | 25.9 | Preclinical |
| CHEMBL2324204 | 7.3 | Ki | 49.8 | Preclinical |
| CHEMBL4556893 | 7.3 | IC50 | 50.0 | Preclinical |
| CHEMBL3980383 | 7.27 | IC50 | 54.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 37 | 101 | 5.8 |
| cell-based format | 28 | 7 | 6.2 |
| assay format | 1 | 1 | 8.4 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 2 | 121 | 4.9 |