Compound Detail
CHEMBL2324207
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CC[C@@H](C)[C@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2cnc[nH]2)NC(=O)[C@@H](CC(=O)O)NC(=O)CC[C@H](C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](Cc2ccc3ccccc3c2)C(=O)NO)NC(=O)[C@@H](CCCNC(=N)N)NC1=O
Basic Information
| ChEMBL ID | CHEMBL2324207 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZCHFLKADFJILAX-LZAOUXPHSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
1352.5
MW (Da)
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 7.64
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Insulin-degrading enzyme CHEMBL1293287 | Ki | 7.64 | 7.0067 | 23.1 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Insulin-degrading enzyme | Ki | = | 23.1 | nM | 7.64 | Inhibition of human recombinant IDE-mediated FRET1 degradation | 23437776 |
| Insulin-degrading enzyme | Ki | = | 171.0 | nM | 6.77 | Inhibition of human recombinant IDE-mediated insulin degradation | 23437776 |
| Insulin-degrading enzyme | Ki | = | 246.0 | nM | 6.61 | Inhibition of human recombinant IDE-mediated fluorescein-Abeta-(1-40)-Lys-biotin... | 23437776 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23437776 | 10.1021/jm301280p | Insulin-degrading enzyme | 3 |
Data from ChEMBL 36 via Core Engine