Assay Detail
Binding
CHEMBL2329965
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Inhibition of human recombinant IDE-mediated FRET1 degradation
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Optimization of peptide hydroxamate inhibitors of insulin-degrading enzyme reveals marked substrate-selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 6.64 | 8.53 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2324220 | — | — | 1 | 8.53 |
| CHEMBL2324207 | — | — | 1 | 7.64 |
| CHEMBL2324201 | — | — | 1 | 7.59 |
| CHEMBL2324206 | — | — | 1 | 7.36 |
| CHEMBL2324204 | — | — | 1 | 7.30 |
| CHEMBL2324209 | — | — | 1 | 7.13 |
| CHEMBL2324219 | — | — | 1 | 7.11 |
| CHEMBL2324205 | — | — | 1 | 7.07 |
| CHEMBL2324203 | — | — | 1 | 7.06 |
| CHEMBL2324202 | — | — | 1 | 6.99 |
| CHEMBL2324213 | — | — | 1 | 6.30 |
| CHEMBL2324208 | — | — | 1 | 5.94 |
| CHEMBL2324218 | — | — | 1 | 5.28 |
| CHEMBL2324214 | — | — | 1 | 5.15 |
| CHEMBL2324212 | — | — | 1 | 5.11 |
| CHEMBL2324211 | — | — | 1 | 4.75 |
| CHEMBL2324210 | — | — | 1 | - |
| CHEMBL2324215 | — | — | 1 | - |
| CHEMBL2324216 | — | — | 1 | - |
| CHEMBL2324217 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2324220 | — | Ki | = | 2.96 | nM | 8.53 |
| CHEMBL2324207 | — | Ki | = | 23.1 | nM | 7.64 |
| CHEMBL2324201 | — | Ki | = | 25.9 | nM | 7.59 |
| CHEMBL2324206 | — | Ki | = | 43.7 | nM | 7.36 |
| CHEMBL2324204 | — | Ki | = | 49.8 | nM | 7.30 |
| CHEMBL2324209 | — | Ki | = | 73.3 | nM | 7.13 |
| CHEMBL2324219 | — | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL2324205 | — | Ki | = | 85.1 | nM | 7.07 |
| CHEMBL2324203 | — | Ki | = | 87.0 | nM | 7.06 |
| CHEMBL2324202 | — | Ki | = | 103.0 | nM | 6.99 |
| CHEMBL2324213 | — | Ki | = | 498.0 | nM | 6.30 |
| CHEMBL2324208 | — | Ki | = | 1150.0 | nM | 5.94 |
| CHEMBL2324218 | — | Ki | = | 5280.0 | nM | 5.28 |
| CHEMBL2324214 | — | Ki | = | 7020.0 | nM | 5.15 |
| CHEMBL2324212 | — | Ki | = | 7750.0 | nM | 5.11 |
| CHEMBL2324211 | — | Ki | = | 18000.0 | nM | 4.75 |
| CHEMBL2324210 | — | Ki | > | 33000.0 | nM | - |
| CHEMBL2324215 | — | Ki | > | 33000.0 | nM | - |
| CHEMBL2324216 | — | Ki | > | 33000.0 | nM | - |
| CHEMBL2324217 | — | Ki | > | 33000.0 | nM | - |