Compound Detail
CHEMBL2324206
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CC(=O)N[C@@H](CCC(=O)NCCNc1cccc2c(S(=O)(=O)O)cccc12)C(=O)N[C@H](Cc1ccc(O)cc1)C(=O)N(C(=O)c1ccccc1)[C@H](Cc1ccccc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)NO
Basic Information
| ChEMBL ID | CHEMBL2324206 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VZHNNIDQCHBLRE-WNDGNIDMSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
1064.2
MW (Da)
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 8.85
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Insulin-degrading enzyme CHEMBL1293287 | Ki | 8.85 | 7.5333 | 1.4 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Insulin-degrading enzyme | Ki | = | 1.4 | nM | 8.85 | Inhibition of human recombinant IDE-mediated fluorescein-Abeta-(1-40)-Lys-biotin... | 23437776 |
| Insulin-degrading enzyme | Ki | = | 43.7 | nM | 7.36 | Inhibition of human recombinant IDE-mediated FRET1 degradation | 23437776 |
| Insulin-degrading enzyme | Ki | = | 410.0 | nM | 6.39 | Inhibition of human recombinant IDE-mediated insulin degradation | 23437776 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23437776 | 10.1021/jm301280p | Insulin-degrading enzyme | 5 |
Data from ChEMBL 36 via Core Engine