Assay Detail
Binding
CHEMBL2329964
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Inhibition of human recombinant IDE-mediated fluorescein-Abeta-(1-40)-Lys-biotin degradation
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Optimization of peptide hydroxamate inhibitors of insulin-degrading enzyme reveals marked substrate-selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.04 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2324206 | — | — | 1 | 8.85 |
| CHEMBL2324220 | — | — | 1 | 7.66 |
| CHEMBL2324201 | — | — | 1 | 7.15 |
| CHEMBL2324203 | — | — | 1 | 6.97 |
| CHEMBL2324204 | — | — | 1 | 6.64 |
| CHEMBL2324207 | — | — | 1 | 6.61 |
| CHEMBL2324205 | — | — | 1 | 6.44 |
| CHEMBL2324202 | — | — | 1 | 6.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2324206 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL2324220 | — | Ki | = | 21.7 | nM | 7.66 |
| CHEMBL2324201 | — | Ki | = | 70.3 | nM | 7.15 |
| CHEMBL2324203 | — | Ki | = | 107.0 | nM | 6.97 |
| CHEMBL2324204 | — | Ki | = | 228.0 | nM | 6.64 |
| CHEMBL2324207 | — | Ki | = | 246.0 | nM | 6.61 |
| CHEMBL2324205 | — | Ki | = | 365.0 | nM | 6.44 |
| CHEMBL2324202 | — | Ki | = | 927.0 | nM | 6.03 |