Assay Detail
Binding
CHEMBL4422591
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of StrepTag-tagged human SARM1 TIR (561 to 724 residues) expressed in NRK1-HEK293T cells assessed as reduction in NADase activity by measuring maximal ADPR conversion pre-incubated up to 120 mins before NAD+ addition and further incubated for 60 mins by HPLC analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
INHIBITORS OF SARM1 NADase ACTIVITY AND USES THEREOF
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.15 | 5.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1219 | RABEPRAZOLE | 4.0 | 1 | 5.50 |
| CHEMBL1201863 | DEXLANSOPRAZOLE | 4.0 | 1 | 5.48 |
| CHEMBL1475252 | TENATOPRAZOLE | 2.0 | 1 | 5.06 |
| CHEMBL4458111 | — | — | 1 | 4.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1219 | RABEPRAZOLE | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL1201863 | DEXLANSOPRAZOLE | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL1475252 | TENATOPRAZOLE | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL4458111 | — | IC50 | = | 28300.0 | nM | 4.55 |