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Target Snapshot

CHEMBL3883320 Target Snapshot

Histone-lysine N-methyltransferase 2A/WDR5 · PROTEIN-PROTEIN INTERACTION · Homo sapiens

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99Compounds
38Assays
5Approved Drugs
92.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt P61964. Use UniProt P61964 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P61964 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Histone-lysine N-methyltransferase 2A/WDR5 as ChEMBL target CHEMBL3883320, mapped to UniProt P61964. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Histone-lysine N-methyltransferase 2A/WDR5
PROTEIN-PROTEIN INTERACTION · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL3883320
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P61964
WD repeat-containing protein 5
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Histone-lysine N-methyltransferase 2A/WDR5 is the right protein anchor across sources, using UniProt P61964 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameHistone-lysine N-methyltransferase 2A/WDR5
Target TypePROTEIN-PROTEIN INTERACTION
OrganismHomo sapiens
UniProtP61964
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelWD repeat-containing protein 5
UniProt AccessionP61964
Component TypeProtein
Sequence Length334 aa

WD repeat-containing protein 5

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Histone-lysine N-methyltransferase 2A/WDR5, mapped to UniProt P61964. ChEMBL maps the protein component as WD repeat-containing protein 5. Sequence length is 334 aa.

Mapped IDP61964
Review nameHistone-lysine N-methyltransferase 2A/WDR5
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

5
Approved
Assay Mix

Activity Type Distribution

IC5092.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3798088 9.05 IC50 0.9 Preclinical
CHEMBL4588661 8.17 IC50 6.8 Preclinical
CHEMBL5562523 8.07 IC50 8.6 Preclinical
CHEMBL5573350 8.01 IC50 9.8 Preclinical
CHEMBL5579746 7.95 IC50 11.3 Preclinical
CHEMBL5572054 7.81 IC50 15.5 Preclinical
CHEMBL5565914 7.76 IC50 17.2 Preclinical
CHEMBL5576035 7.73 IC50 18.8 Preclinical
CHEMBL5575058 7.6 IC50 25.2 Preclinical
CHEMBL5572530 7.57 IC50 26.9 Preclinical
Distribution

pChEMBL Value Distribution

4
5.0
6
5.5
8
6.0
14
6.5
7
7.0
7
7.5
3
8.0
0
8.5
1
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

RABEPRAZOLE
CHEMBL1219
Approved 1999
Properties Compare Identifier
Assay Landscape

Assay Landscape

38
Total Assays
72
Tested Compounds
1
Assay Types
Binding — 38 assays, 72 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 32 8 5.8
protein format 6 64 6.3

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine