Compound Detail
CHEMBL1201022
PHENAZOPYRIDINE HYDROCHLORIDE 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL1201022 |
| Name | PHENAZOPYRIDINE HYDROCHLORIDE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | QQBPIHBUCMDKFG-GEEYTBSJSA-N |
| Therapeutic | ✓ Yes |
| Parent Compound | CHEMBL1242 |
| Active Moiety | CHEMBL1242 |
2
Targets
3
Activities
2
Assay Types
0
PK Parameters
14
Publications
11
Known Names
1
Indications
1
Mechanisms
Molecular Properties
213.2
MW (Da)
2.66
ALogP
5
HBA
2
HBD
89.7
PSA (Ų)
0.75
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1987 |
| Availability | Discontinued |
| Chirality | Achiral |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Sodium channel alpha subunit blocker | BLOCKER | Sodium channel alpha subunit | ✓ | ✓ |
Indications
Urinary Tract Infections
Activity Summary
IC50 2 meas. best 4.26
Ki 1 meas. best 4.16
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Snake venom metalloproteinase BaP1 CHEMBL2079851 | IC50 | 4.26 | 4.26 | 54300.0 | 1 |
| NAD(+) hydrolase SARM1 CHEMBL4523350 | Ki | 4.16 | 4.16 | 70000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Snake venom metalloproteinase BaP1 | IC50 | = | 54300.0 | nM | 4.26 | Inhibition of snake venom BaP1 using Abz-Ala-Gly-Leu-Ala-Nba as substrate incuba... | 24900507 |
| NAD(+) hydrolase SARM1 | Ki | = | 70000.0 | nM | 4.16 | Competitive inhibition of recombinant human SARM1 TIR domain (561 to 724 residue... | 32828421 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 32828421 | 10.1016/j.bmc.2020.115644 | NAD(+) hydrolase SARM1 | 3 |
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| 20553011 | 10.1021/tx1000865 | Hepatotoxicity | 1 |
| 20843939 | 10.1124/dmd.110.035113 | Hepatotoxicity | 1 |
| 22194678 | 10.1371/journal.pcbi.1002310 | Hepatotoxicity | 1 |
| 24900507 | 10.1021/ml300068r | Snake venom metalloproteinase BaP1 | 1 |
| 23571415 | 10.1124/mol.112.084152 | Solute carrier organic anion transporter family member 1B1 | 1 |
| 23571415 | 10.1124/mol.112.084152 | Solute carrier organic anion transporter family member 1B3 | 1 |
| - | 10.1101/2020.04.03.023846 | SARS-CoV-2 | 1 |
| - | 10.21203/rs.3.rs-23951/v1 | SARS-CoV-2 | 1 |
| 27397500 | 10.1016/j.bmcl.2016.06.088 | Cytochrome P450 3A4 | 1 |
| 27397500 | 10.1016/j.bmcl.2016.06.088 | Cytochrome P450 2D6 | 1 |
| 27397500 | 10.1016/j.bmcl.2016.06.088 | Cytochrome P450 2C9 | 1 |
| - | 10.6019/CHEMBL4495564 | Replicase polyprotein 1ab | 1 |
Data from ChEMBL 36 via Core Engine