Assay Detail
Functional
CHEMBL1639019
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Antimicrobial activity against Trypanosoma brucei
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Cross-resistance to nitro drugs and implications for treatment of human African trypanosomiasis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 5.92 | 9.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 9.02 |
| CHEMBL869 | NITROFURAZONE | 4.0 | 1 | 6.51 |
| CHEMBL23330 | TRETAZICAR | 2.0 | 1 | 6.27 |
| CHEMBL1631696 | FEXINIDAZOLE SULFONE | — | 1 | 6.21 |
| CHEMBL1631694 | FEXINIDAZOLE | 4.0 | 1 | 6.00 |
| CHEMBL1631695 | FEXINIDAZOLE SULFOXIDE | — | 1 | 5.85 |
| CHEMBL290960 | NIFURTIMOX | 4.0 | 1 | 5.62 |
| CHEMBL830 | EFLORNITHINE | 4.0 | 1 | 4.79 |
| CHEMBL110 | BENZNIDAZOLE | 4.0 | 1 | 4.52 |
| CHEMBL227875 | PRETOMANID | 4.0 | 1 | 4.42 |
| CHEMBL137 | METRONIDAZOLE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | EC50 | = | 0.95 | nM | 9.02 |
| CHEMBL869 | NITROFURAZONE | EC50 | = | 310.0 | nM | 6.51 |
| CHEMBL23330 | TRETAZICAR | EC50 | = | 540.0 | nM | 6.27 |
| CHEMBL1631696 | FEXINIDAZOLE SULFONE | EC50 | = | 620.0 | nM | 6.21 |
| CHEMBL1631694 | FEXINIDAZOLE | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1631695 | FEXINIDAZOLE SULFOXIDE | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL290960 | NIFURTIMOX | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL830 | EFLORNITHINE | EC50 | = | 16400.0 | nM | 4.79 |
| CHEMBL110 | BENZNIDAZOLE | EC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL227875 | PRETOMANID | EC50 | = | 37800.0 | nM | 4.42 |
| CHEMBL137 | METRONIDAZOLE | EC50 | > | 500000.0 | nM | - |