Assay Detail
Functional
CHEMBL1639020
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Antimicrobial activity against Trypanosoma brucei NfxR1
12
Total Activities
11
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Cross-resistance to nitro drugs and implications for treatment of human African trypanosomiasis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 4.95 | 5.58 |
| MIC | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 5.58 |
| CHEMBL869 | NITROFURAZONE | 4.0 | 1 | 5.43 |
| CHEMBL23330 | TRETAZICAR | 2.0 | 1 | 5.10 |
| CHEMBL1631696 | FEXINIDAZOLE SULFONE | — | 1 | 5.02 |
| CHEMBL830 | EFLORNITHINE | 4.0 | 1 | 4.92 |
| CHEMBL1631695 | FEXINIDAZOLE SULFOXIDE | — | 1 | 4.74 |
| CHEMBL290960 | NIFURTIMOX | 4.0 | 2 | 4.70 |
| CHEMBL1631694 | FEXINIDAZOLE | 4.0 | 1 | 4.58 |
| CHEMBL227875 | PRETOMANID | 4.0 | 1 | 4.52 |
| CHEMBL110 | BENZNIDAZOLE | 4.0 | 1 | - |
| CHEMBL137 | METRONIDAZOLE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL869 | NITROFURAZONE | EC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL23330 | TRETAZICAR | EC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL1631696 | FEXINIDAZOLE SULFONE | EC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL830 | EFLORNITHINE | EC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL1631695 | FEXINIDAZOLE SULFOXIDE | EC50 | = | 18400.0 | nM | 4.74 |
| CHEMBL290960 | NIFURTIMOX | EC50 | = | 20100.0 | nM | 4.70 |
| CHEMBL1631694 | FEXINIDAZOLE | EC50 | = | 26600.0 | nM | 4.58 |
| CHEMBL227875 | PRETOMANID | EC50 | = | 30500.0 | nM | 4.52 |
| CHEMBL110 | BENZNIDAZOLE | EC50 | = | 154000.0 | nM | - |
| CHEMBL137 | METRONIDAZOLE | EC50 | > | 500000.0 | nM | - |
| CHEMBL290960 | NIFURTIMOX | MIC | = | 15.2 | ug.mL-1 | - |