Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4036945

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antitrypanosomal activity against Trypanosoma cruzi Tulahuen amastigotes infected in mouse 3T3 cells after 6 days by beta galactosidase reporter asay
46
Total Activities
23
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma cruzi
Confidence 1 — Organism
Curated By Autocuration

Target

Trypanosoma cruzi (CHEMBL368)
Type ORGANISM
Organism Trypanosoma cruzi

Publication

New Class of Antitrypanosomal Agents Based on Imidazopyridines.
Silva DG, Gillespie JR, Ranade RM, Herbst ZM, Nguyen UTT, Buckner FS, Montanari CA, Gelb MH.
ACS Med Chem Lett (2017) 8 : 766 -770
PubMed 28740614 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC90 23 - -
EC50 23 5.79 7.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4094238 2 7.05
CHEMBL4076345 2 6.77
CHEMBL4105314 2 6.41
CHEMBL4082010 2 6.24
CHEMBL110 BENZNIDAZOLE 4.0 2 6.16
CHEMBL4060167 2 6.15
CHEMBL4090343 2 6.03
CHEMBL4088394 2 6.00
CHEMBL4063594 2 5.99
CHEMBL4103875 2 5.97
CHEMBL4066834 2 5.65
CHEMBL4100019 2 5.60
CHEMBL4099158 2 5.57
CHEMBL4066533 2 5.56
CHEMBL4076045 2 5.55
CHEMBL4066124 2 5.53
CHEMBL4087495 2 5.51
CHEMBL4079619 2 5.35
CHEMBL4061806 2 5.20
CHEMBL4076783 2 5.13
CHEMBL4089870 2 5.04
CHEMBL4064993 2 5.00
CHEMBL4081060 2 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4094238 EC50 = 90.0 nM 7.05
CHEMBL4076345 EC50 = 170.0 nM 6.77
CHEMBL4105314 EC50 = 390.0 nM 6.41
CHEMBL4082010 EC50 = 570.0 nM 6.24
CHEMBL110 BENZNIDAZOLE EC50 = 690.0 nM 6.16
CHEMBL4060167 EC50 = 710.0 nM 6.15
CHEMBL4090343 EC50 = 940.0 nM 6.03
CHEMBL4088394 EC50 = 1000.0 nM 6.00
CHEMBL4063594 EC50 = 1020.0 nM 5.99
CHEMBL4103875 EC50 = 1080.0 nM 5.97
CHEMBL4066834 EC50 = 2240.0 nM 5.65
CHEMBL4100019 EC50 = 2530.0 nM 5.60
CHEMBL4099158 EC50 = 2680.0 nM 5.57
CHEMBL4066533 EC50 = 2750.0 nM 5.56
CHEMBL4076045 EC50 = 2840.0 nM 5.55
CHEMBL4066124 EC50 = 2950.0 nM 5.53
CHEMBL4087495 EC50 = 3100.0 nM 5.51
CHEMBL4079619 EC50 = 4460.0 nM 5.35
CHEMBL4061806 EC50 = 6270.0 nM 5.20
CHEMBL4076783 EC50 = 7340.0 nM 5.13
CHEMBL4089870 EC50 = 9060.0 nM 5.04
CHEMBL4064993 EC50 = 9940.0 nM 5.00
CHEMBL4063594 EC90 = 1.61 uM -
CHEMBL4088394 EC90 = 1.58 uM -
CHEMBL4060167 EC90 = 0.88 uM -
CHEMBL4066124 EC90 = 6.01 uM -
CHEMBL4087495 EC90 = 4.53 uM -
CHEMBL4103875 EC90 = 1.73 uM -
CHEMBL4079619 EC90 = 6.44 uM -
CHEMBL4066533 EC90 = 12.28 uM -
CHEMBL4076045 EC90 = 4.4 uM -
CHEMBL4066834 EC90 = 2.57 uM -
CHEMBL4105314 EC90 = 0.6 uM -
CHEMBL4081060 EC90 > 20.0 uM -
CHEMBL4099158 EC90 = 3.92 uM -
CHEMBL4076783 EC90 > 20.0 uM -
CHEMBL4090343 EC90 = 1.36 uM -
CHEMBL4064993 EC90 > 20.0 uM -
CHEMBL4076345 EC90 = 0.64 uM -
CHEMBL4094238 EC90 = 0.15 uM -
CHEMBL4100019 EC90 > 20.0 uM -
CHEMBL110 BENZNIDAZOLE EC90 = 1.36 uM -
CHEMBL4061806 EC90 > 20.0 uM -
CHEMBL4089870 EC90 > 20.0 uM -
CHEMBL4081060 EC50 > 20000.0 nM -
CHEMBL4082010 EC90 = 1.52 uM -