Compound Detail
CHEMBL4094238
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Basic Information
| ChEMBL ID | CHEMBL4094238 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AGWLAOLPCWZIGV-NSHDSACASA-N |
2
Targets
2
Activities
1
Assay Types
4
PK Parameters
10
Publications
0
Known Names
Molecular Properties
361.3
MW (Da)
3.25
ALogP
4
HBA
1
HBD
62.5
PSA (Ų)
0.76
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 7.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Trypanosoma brucei brucei CHEMBL612851 | EC50 | 7.7 | 7.7 | 20.0 | 1 |
| Trypanosoma cruzi CHEMBL368 | EC50 | 7.05 | 7.05 | 90.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | 21589.47 | ng.hr.mL-1 | Mus musculus |
| Cmax | 5700.0 | nM | Mus musculus |
| Fu | 0.099 | - | Mus musculus |
| T1/2 | 1.0 | hr | Mus musculus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Trypanosoma brucei brucei | EC50 | = | 20.0 | nM | 7.7 | Antitrypanosomal activity against Trypanosoma brucei brucei BF427 after 48 hrs b... | 28740614 |
| Trypanosoma cruzi | EC50 | = | 90.0 | nM | 7.05 | Antitrypanosomal activity against Trypanosoma cruzi Tulahuen amastigotes infecte... | 28740614 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 28740614 | 10.1021/acsmedchemlett.7b00202 | Plasma | 6 |
| 28740614 | 10.1021/acsmedchemlett.7b00202 | Trypanosoma cruzi | 3 |
| 28740614 | 10.1021/acsmedchemlett.7b00202 | No relevant target | 3 |
| 28740614 | 10.1021/acsmedchemlett.7b00202 | Mus musculus | 3 |
| 28740614 | 10.1021/acsmedchemlett.7b00202 | Trypanosoma brucei brucei | 2 |
| 28740614 | 10.1021/acsmedchemlett.7b00202 | Liver | 2 |
| 28740614 | 10.1021/acsmedchemlett.7b00202 | Unchecked | 1 |
| 28740614 | 10.1021/acsmedchemlett.7b00202 | HepG2 | 1 |
| 28740614 | 10.1021/acsmedchemlett.7b00202 | Brain | 1 |
| 28740614 | 10.1021/acsmedchemlett.7b00202 | ADMET | 1 |
Data from ChEMBL 36 via Core Engine