Assay Detail
Functional
CHEMBL4840639
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma cruzi amastigotes infected in BSR cells assessed as inhibition of replication of intracellular amastigotes incubated for 72 hrs by fluorescence based analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma cruzi |
| Cell Type | BSR |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of Mannich base-type derivatives containing imidazole and benzimidazole as lead compounds for drug discovery in Chagas Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.39 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL110 | BENZNIDAZOLE | 4.0 | 1 | 6.30 |
| CHEMBL4856014 | — | — | 1 | 5.48 |
| CHEMBL4867967 | — | — | 1 | 5.21 |
| CHEMBL4853501 | — | — | 1 | 5.04 |
| CHEMBL4853502 | — | — | 1 | 4.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL110 | BENZNIDAZOLE | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4856014 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4867967 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL4853501 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL4853502 | — | IC50 | = | 12200.0 | nM | 4.91 |