Assay Detail
Functional
CHEMBL1665373
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Antiprotozoal activity against Trypanosoma cruzi Tulahuen C2C4 amastigotes
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma cruzi |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Trypanothione reductase high-throughput screening campaign identifies novel classes of inhibitors with antiparasitic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.55 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL110 | BENZNIDAZOLE | 4.0 | 1 | 8.74 |
| CHEMBL1098695 | — | — | 1 | 7.00 |
| CHEMBL522887 | — | — | 1 | 5.22 |
| CHEMBL1652417 | — | — | 1 | 5.22 |
| CHEMBL1652425 | — | — | 1 | 5.10 |
| CHEMBL599883 | — | — | 1 | 4.82 |
| CHEMBL1652416 | — | — | 1 | 4.72 |
| CHEMBL247772 | — | — | 1 | 4.72 |
| CHEMBL602365 | — | — | 1 | 4.42 |
| CHEMBL1652415 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL110 | BENZNIDAZOLE | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL1098695 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL522887 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL1652417 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL1652425 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL599883 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL1652416 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL247772 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL602365 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL1652415 | — | IC50 | > | 30000.0 | nM | - |