Assay Detail
Functional
CHEMBL4313830
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma brucei bloodstream form assessed as parasite growth inhibition incubated for 72 hrs by resazurin dye based assay
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a benzothiophene-flavonol halting miltefosine and antimonial drug resistance in Leishmania parasites through the application of medicinal chemistry, screening and genomics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 39 | 5.65 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL110 | BENZNIDAZOLE | 4.0 | 1 | 7.80 |
| CHEMBL4450031 | — | — | 1 | 6.40 |
| CHEMBL4464312 | — | — | 1 | 6.10 |
| CHEMBL4567447 | — | — | 1 | 5.89 |
| CHEMBL4441917 | — | — | 1 | 5.89 |
| CHEMBL4473268 | — | — | 1 | 5.85 |
| CHEMBL4469979 | — | — | 1 | 5.82 |
| CHEMBL4447054 | — | — | 1 | 5.82 |
| CHEMBL4565781 | — | — | 1 | 5.77 |
| CHEMBL4439246 | — | — | 1 | 5.70 |
| CHEMBL4575467 | — | — | 1 | 5.68 |
| CHEMBL4458341 | — | — | 1 | 5.58 |
| CHEMBL4539604 | — | — | 1 | 5.55 |
| CHEMBL4439388 | — | — | 1 | 5.52 |
| CHEMBL4590171 | — | — | 1 | 5.52 |
| CHEMBL4592506 | — | — | 1 | 5.51 |
| CHEMBL4448565 | — | — | 1 | 5.51 |
| CHEMBL4453866 | — | — | 1 | 5.48 |
| CHEMBL4588892 | — | — | 1 | 5.47 |
| CHEMBL4592720 | — | — | 1 | 5.43 |
| CHEMBL4575126 | — | — | 1 | 5.41 |
| CHEMBL4541910 | — | — | 1 | 5.35 |
| CHEMBL4446646 | — | — | 1 | 5.31 |
| CHEMBL4471364 | — | — | 1 | 5.31 |
| CHEMBL4448476 | — | — | 1 | 5.27 |
| CHEMBL4444621 | — | — | 1 | 5.24 |
| CHEMBL125 | MILTEFOSINE | 4.0 | 1 | 4.47 |
| CHEMBL4531258 | — | — | 1 | - |
| CHEMBL4465877 | — | — | 1 | - |
| CHEMBL4459417 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL110 | BENZNIDAZOLE | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4450031 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4464312 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4567447 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4441917 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4473268 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4469979 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4447054 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4565781 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4439246 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4575467 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4458341 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4539604 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4439388 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4590171 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4592506 | — | EC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4448565 | — | EC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4453866 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4588892 | — | EC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4592720 | — | EC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL4575126 | — | EC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4541910 | — | EC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL4446646 | — | EC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL4471364 | — | EC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL4448476 | — | EC50 | = | 5340.0 | nM | 5.27 |
| CHEMBL4444621 | — | EC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL125 | MILTEFOSINE | EC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL4567834 | — | EC50 | - | — | - | |
| CHEMBL4538581 | — | EC50 | - | — | - | |
| CHEMBL4457377 | — | EC50 | - | — | - | |
| CHEMBL4520438 | — | EC50 | - | — | - | |
| CHEMBL4563463 | — | EC50 | - | — | - | |
| CHEMBL4519474 | — | EC50 | - | — | - | |
| CHEMBL4438959 | — | EC50 | - | — | - | |
| CHEMBL4445329 | — | EC50 | - | — | - | |
| CHEMBL4450073 | — | EC50 | - | — | - | |
| CHEMBL4459417 | — | EC50 | - | — | - | |
| CHEMBL4465877 | — | EC50 | - | — | - | |
| CHEMBL4531258 | — | EC50 | - | — | - |