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Assay Detail

CHEMBL2045407

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antitrypanosomal activity against Trypanosoma cruzi Tulahuen C2C4 intracellular amastigotes infected in rat L6 cells after 4 days by photometry
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma cruzi
Cell Type L6
Confidence 1 — Organism
Curated By Autocuration

Target

Trypanosoma cruzi (CHEMBL368)
Type ORGANISM
Organism Trypanosoma cruzi

Publication

Design and synthesis of new (E)-cinnamic N-acylhydrazones as potent antitrypanosomal agents.
Carvalho SA, Feitosa LO, Soares M, Costa TE, Henriques MG, Salomão K, de Castro SL, Kaiser M, Brun R, Wardell JL, Wardell SM, Trossini GH, Andricopulo AD, da Silva EF, Fraga CA.
Eur J Med Chem (2012) 54 : 512 -521
PubMed 22727447 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 29 4.73 6.91

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL110 BENZNIDAZOLE 4.0 1 6.91
CHEMBL2042780 1 5.18
CHEMBL2042787 1 4.40
CHEMBL2042782 1 4.21
CHEMBL2042786 1 4.16
CHEMBL2042785 1 4.14
CHEMBL2042777 1 4.09
CHEMBL2042798 1 -
CHEMBL2042784 1 -
CHEMBL2042799 1 -
CHEMBL2042800 1 -
CHEMBL1172118 1 -
CHEMBL2042774 1 -
CHEMBL2042775 1 -
CHEMBL2042778 1 -
CHEMBL2042779 1 -
CHEMBL2042781 1 -
CHEMBL2042783 1 -
CHEMBL2042788 1 -
CHEMBL2042789 1 -
CHEMBL2042790 1 -
CHEMBL2042791 1 -
CHEMBL2042792 1 -
CHEMBL2042793 1 -
CHEMBL2042794 1 -
CHEMBL2042795 1 -
CHEMBL2042796 1 -
CHEMBL2042776 1 -
CHEMBL2042797 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL110 BENZNIDAZOLE IC50 = 122.0 nM 6.91
CHEMBL2042780 IC50 = 6600.0 nM 5.18
CHEMBL2042787 IC50 = 40000.0 nM 4.40
CHEMBL2042782 IC50 = 61000.0 nM 4.21
CHEMBL2042786 IC50 = 70000.0 nM 4.16
CHEMBL2042785 IC50 = 73000.0 nM 4.14
CHEMBL2042777 IC50 = 81000.0 nM 4.09
CHEMBL2042798 IC50 - -
CHEMBL2042784 IC50 > 100000.0 nM -
CHEMBL2042799 IC50 - -
CHEMBL2042800 IC50 - -
CHEMBL1172118 IC50 > 100000.0 nM -
CHEMBL2042774 IC50 > 100000.0 nM -
CHEMBL2042775 IC50 > 100000.0 nM -
CHEMBL2042778 IC50 > 100000.0 nM -
CHEMBL2042779 IC50 > 100000.0 nM -
CHEMBL2042781 IC50 > 100000.0 nM -
CHEMBL2042783 IC50 > 100000.0 nM -
CHEMBL2042788 IC50 - -
CHEMBL2042789 IC50 - -
CHEMBL2042790 IC50 - -
CHEMBL2042791 IC50 - -
CHEMBL2042792 IC50 - -
CHEMBL2042793 IC50 - -
CHEMBL2042794 IC50 - -
CHEMBL2042795 IC50 - -
CHEMBL2042796 IC50 - -
CHEMBL2042776 IC50 - -
CHEMBL2042797 IC50 - -