Assay Detail

CHEMBL1675116

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Binding

Binding affinity to Mycobacterium tuberculosis CYP51

ChEMBL ↗

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Target

Sterol 14alpha-demethylase (CHEMBL5090) ↗

Open DB target context

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Sterol 14alpha-demethylase (CHEMBL5090) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Sterol 14alpha-demethylase

CHEMBL5090

Anchored from Assay target.

Protein identity Sterol 14alpha-demethylase

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Mycobacterium tuberculosis
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Sterol 14alpha-demethylase (CHEMBL5090) ↗

Type	SINGLE PROTEIN
Organism	Mycobacterium tuberculosis

Publication

Identification, characterization, and azole-binding properties of Mycobacterium smegmatis CYP164A2, a homolog of ML2088, the sole cytochrome P450 gene of Mycobacterium leprae.

Warrilow AG, Jackson CJ, Parker JE, Marczylo TH, Kelly DE, Lamb DC, Kelly SL.
Antimicrob Agents Chemother (2009) 53 : 1157 -1164
PubMed 19075057 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Kd	4	6.70	6.70

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL104	CLOTRIMAZOLE	4.0	1	6.70
CHEMBL808	ECONAZOLE	4.0	1	6.70
CHEMBL106	FLUCONAZOLE	4.0	1	6.70
CHEMBL91	MICONAZOLE	4.0	1	6.70

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL104	CLOTRIMAZOLE	Kd	=	200.0	nM	6.70
CHEMBL808	ECONAZOLE	Kd	=	200.0	nM	6.70
CHEMBL106	FLUCONAZOLE	Kd	=	200.0	nM	6.70
CHEMBL91	MICONAZOLE	Kd	=	200.0	nM	6.70