Skip to main content
Free research Free research Free target review with research home and workspace preview
Quick search ChEMBL 36
Loading Target Snapshot...
Querying ChEMBL database. This may take a few seconds.
Target Snapshot

CHEMBL4523494 Target Snapshot

7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase · SINGLE PROTEIN · Homo sapiens

Back to Search Search this target Browse approvals Evidence Card
90Compounds
2Assays
7Approved Drugs
91.0Activities
Free Research Context

Research home keeps recent targets

This target will appear in recent viewed items on this browser. Use the demo workspace to preview watch rules and decision queues.

Research home Demo workspace
Navigation

Switch target

Move to another high-traffic target or paste a specific ChEMBL target ID.

Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q9UNU6. Use UniProt Q9UNU6 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q9UNU6 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase as ChEMBL target CHEMBL4523494, mapped to UniProt Q9UNU6. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL4523494
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q9UNU6
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase is the right protein anchor across sources, using UniProt Q9UNU6 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

Open Review-ready Card
Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred Name7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtQ9UNU6
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein Label7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
UniProt AccessionQ9UNU6
Component TypeProtein
Sequence Length501 aa

7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase, mapped to UniProt Q9UNU6. Sequence length is 501 aa.

Mapped IDQ9UNU6
Review name7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

7
Approved
Assay Mix

Activity Type Distribution

IC5091.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4436614 9.77 IC50 0.17 Preclinical
CHEMBL4453090 9.7 IC50 0.2 Preclinical
CHEMBL4455566 9.7 IC50 0.2 Preclinical
CHEMBL4469186 9.7 IC50 0.2 Preclinical
CHEMBL4566069 9.7 IC50 0.2 Preclinical
CHEMBL4445397 9.66 IC50 0.22 Preclinical
CHEMBL4459136 9.6 IC50 0.25 Preclinical
CHEMBL4580955 9.6 IC50 0.25 Preclinical
CHEMBL4452352 9.55 IC50 0.28 Preclinical
CHEMBL4450590 9.51 IC50 0.31 Preclinical
Distribution

pChEMBL Value Distribution

6
5.0
7
5.5
3
6.0
9
6.5
4
7.0
6
7.5
12
8.0
8
8.5
26
9.0
10
9.5
pChEMBL
Approved Drugs

Approved Drugs

ECONAZOLE
CHEMBL808
Approved 1982
Properties Compare Identifier
CLOTRIMAZOLE
CHEMBL104
Approved 1975
Properties Compare Identifier
Assay Landscape

Assay Landscape

2
Total Assays
90
Tested Compounds
1
Assay Types
Binding — 2 assays, 90 compounds
BAO Format Assays Compounds Avg pChEMBL
microsome format 2 90 8.1

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine