Assay Detail
ADMET
CHEMBL4434391
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CYP3A4 (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Strategies for the development of highly selective cytochrome P450 inhibitors: Several CYP targets in current research.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.21 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL104 | CLOTRIMAZOLE | 4.0 | 1 | 7.30 |
| CHEMBL157101 | KETOCONAZOLE | 4.0 | 1 | 6.70 |
| CHEMBL808 | ECONAZOLE | 4.0 | 1 | 6.37 |
| CHEMBL91 | MICONAZOLE | 4.0 | 1 | 6.07 |
| CHEMBL106 | FLUCONAZOLE | 4.0 | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL104 | CLOTRIMAZOLE | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL157101 | KETOCONAZOLE | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL808 | ECONAZOLE | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL91 | MICONAZOLE | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL106 | FLUCONAZOLE | IC50 | = | 25000.0 | nM | 4.60 |