Assay Detail
Binding
CHEMBL5253448
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at TRPM8 (unknown origin)
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Transient receptor potential cation channel subfamily M member 8 (CHEMBL1075319) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Transient Receptor Potential Melastatin 8 Channel (TRPM8) Modulation: Cool Entryway for Treating Pain and Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.66 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5275380 | — | — | 1 | 9.52 |
| CHEMBL3353597 | — | — | 1 | 8.08 |
| CHEMBL190461 | CANNABIDIOL | 4.0 | 1 | 7.22 |
| CHEMBL375696 | — | — | 1 | 6.82 |
| CHEMBL465718 | DELTA9-TETRAHYDROCANNABINOLIC ACID A | — | 1 | 6.82 |
| CHEMBL5269402 | — | — | 1 | 6.82 |
| CHEMBL497318 | CANNABIGEROL | 2.0 | 1 | 6.80 |
| CHEMBL465 | DRONABINOL | 4.0 | 1 | 6.80 |
| CHEMBL808 | ECONAZOLE | 4.0 | 1 | 6.38 |
| CHEMBL5284265 | — | — | 1 | 6.16 |
| CHEMBL258502 | — | — | 1 | 6.10 |
| CHEMBL1779158 | — | — | 1 | 6.10 |
| CHEMBL294199 | CAPSAICIN | 4.0 | 1 | 6.00 |
| CHEMBL5274774 | — | — | 1 | 5.22 |
| CHEMBL104 | CLOTRIMAZOLE | 4.0 | 1 | 5.10 |
| CHEMBL5267089 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5275380 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL3353597 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL190461 | CANNABIDIOL | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL375696 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL465718 | DELTA9-TETRAHYDROCANNABINOLIC ACID A | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL5269402 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL497318 | CANNABIGEROL | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL465 | DRONABINOL | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL808 | ECONAZOLE | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL5284265 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL258502 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL1779158 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL294199 | CAPSAICIN | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL5274774 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL104 | CLOTRIMAZOLE | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL5267089 | — | IC50 | < | 20.0 | nM | - |