Compound Detail
CHEMBL5275380
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
O=S(=O)(c1ccc(-c2nnn[nH]2)cc1)N(Cc1ccc(OC(F)(F)F)cc1)c1ncc2ccccc2c1C1CC1
Basic Information
| ChEMBL ID | CHEMBL5275380 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HLLKNPAVDRASLS-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
566.6
MW (Da)
5.59
ALogP
7
HBA
1
HBD
114.0
PSA (Ų)
0.26
QED
2
Ro5 Violations
8
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 9.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Transient receptor potential cation channel subfamily M member 8 CHEMBL1075319 | IC50 | 9.52 | 9.52 | 0.3 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Transient receptor potential cation channel subfamily M member 8 | IC50 | = | 0.3 | nM | 9.52 | Antagonist activity at TRPM8 (unknown origin) | 27437828 |
| Transient receptor potential cation channel subfamily M member 8 | IC50 | = | 0.3 | nM | 9.52 | Inhibition Assay: The functional activity of a test compound was determined by m... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 27437828 | 10.1021/acs.jmedchem.6b00305 | Transient receptor potential cation channel subfamily M member 8 | 1 |
Data from ChEMBL 36 via Core Engine