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Target Snapshot

CHEMBL1681615 Target Snapshot

Mycocyclosin synthase · SINGLE PROTEIN · Mycobacterium tuberculosis

75Compounds
7Assays
4Approved Drugs
40.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt P9WPP7. Use UniProt P9WPP7 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P9WPP7 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Mycocyclosin synthase as ChEMBL target CHEMBL1681615, mapped to UniProt P9WPP7. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Mycocyclosin synthase
SINGLE PROTEIN · Mycobacterium tuberculosis
As of 2026-09-13
ChEMBL target ID
CHEMBL1681615
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P9WPP7
Mycocyclosin synthase
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Mycocyclosin synthase is the right protein anchor across sources, using UniProt P9WPP7 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelMycocyclosin synthase
UniProt AccessionP9WPP7
Component TypeProtein
Sequence Length396 aa

Mycocyclosin synthase

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Mycocyclosin synthase, mapped to UniProt P9WPP7. Sequence length is 396 aa.

Mapped IDP9WPP7
Review nameMycocyclosin synthase
OrganismMycobacterium tuberculosis
Clinical Profile

Clinical Phase Distribution

4
Approved
Assay Mix

Activity Type Distribution

KD40.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3806115 7.82 Kd 15.0 Preclinical
CHEMBL3804971 7.47 Kd 34.0 Preclinical
CHEMBL91 7.14 Kd 73.0 Approved
CHEMBL104 7.14 Kd 73.0 Approved
CHEMBL808 7.14 Kd 73.0 Approved
CHEMBL3805159 6.54 Kd 290.0 Preclinical
CHEMBL106 5.22 Kd 6000.0 Approved
CHEMBL3805279 5.2 Kd 6300.0 Preclinical
CHEMBL3805931 4.97 Kd 10600.0 Preclinical
CHEMBL3806191 4.85 Kd 14000.0 Preclinical
Distribution

pChEMBL Value Distribution

3
5.0
0
5.5
1
6.0
1
6.5
4
7.0
1
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

ECONAZOLE
CHEMBL808
Approved 1982
CLOTRIMAZOLE
CHEMBL104
Approved 1975
MICONAZOLE
CHEMBL91
Approved 1974
Assay Landscape

Assay Landscape

7
Total Assays
36
Tested Compounds
1
Assay Types
Binding — 7 assays, 36 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 5 32 4.4
single protein format 2 4 6.7

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine