Assay Detail
Binding
CHEMBL2211451
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Binding affinity to sigma 1 receptor
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL287) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
From α4β2 Nicotinic Ligands to the Discovery of σ1 Receptor Ligands: Pharmacophore Analysis and Rational Design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.06 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2203549 | — | — | 1 | 8.68 |
| CHEMBL60542 | (+)-PENTAZOCINE | — | 1 | 8.51 |
| CHEMBL76806 | — | — | 1 | 8.44 |
| CHEMBL814 | FLUVOXAMINE | 4.0 | 1 | 7.44 |
| CHEMBL809 | SERTRALINE | 4.0 | 1 | 7.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2203549 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL60542 | (+)-PENTAZOCINE | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL76806 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL814 | FLUVOXAMINE | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL809 | SERTRALINE | Ki | = | 57.0 | nM | 7.24 |