Assay Detail
Functional
CHEMBL3430608
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of calcium current (ICaL) measured using whole-cell patch clamp experiments in isolated guinea pig ventricular myocytes
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Heart |
| Cell Type | Ventricular myocyte |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-dependent L-type calcium channel subunit alpha-1C (CHEMBL2366456) ↗| Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
Publication
Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 5.31 | 5.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL814 | FLUVOXAMINE | 4.0 | 1 | 5.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL814 | FLUVOXAMINE | IC50 | = | 4900.0 | nM | 5.31 |