Review anchor
Sigma non-opioid intracellular receptor 1
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-13
Evidence Snapshot
Sigma non-opioid intracellular receptor 1
CHEMBL3602
SINGLE PROTEIN
Rattus norvegicus
Identity Layer
Cross-source identity
Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Sigma non-opioid intracellular receptor 1 as ChEMBL target CHEMBL3602, mapped to UniProt Q9R0C9. Disease framing currently uses the Open Targets-ready proxy contract.
ChEMBL target ID
CHEMBL3602
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine
As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q9R0C9
Sigma non-opioid intracellular receptor 1
UniProt accession via ChEMBL component mapping
As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy
As of 2026-09-13
www.ebi.ac.uk
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Review-ready Target Rationale
Why Sigma non-opioid intracellular receptor 1 matters
Sigma non-opioid intracellular receptor 1 is reviewed as Sigma non-opioid intracellular receptor 1 (UniProt Q9R0C9); the current evidence base includes 15 approved drugs, 1251 compounds, and 198 assays, with lead potency reaching pChEMBL 11.0.
Protein context
Sigma non-opioid intracellular receptor 1
Sigma non-opioid intracellular receptor 1 Sequence length is 223 aa.
Review this target as Sigma non-opioid intracellular receptor 1, mapped to UniProt Q9R0C9. Sequence length is 223 aa.
Protein source · UniProt accession via ChEMBL component mapping
UniProt Q9R0C9
Protein
Disease context
Disease signal
Disease relevance is not yet populated for this evidence card.
This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
ChEMBL target recordActivity base
Portfolio and assay base
ChEMBL currently tracks 15 approved drugs, 1251 compounds, and 198 assays for this target. The dominant activity type is KI. CHEMBL372700 is the current potency anchor at pChEMBL 11.0.
Use CHEMBL372700 as the tractability anchor when discussing potency (pChEMBL 11.0).
Activity source · ChEMBL 36 via Core Engine
15 approved
pChEMBL 11.0
Source Guidance
Start with the right source
Pick the first block or linked source that matches the review question in front of you.
Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution
Start with the review rationale when you need to explain why Sigma non-opioid intracellular receptor 1 matters before drilling into raw source blocks.
Jump to Review RationaleNeed stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping
Go back to the target snapshot when you need the naming and mapping contract behind UniProt Q9R0C9, not just the summarized rationale.
Open Protein ContextNeed disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy
Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.
Open Disease ContextSnapshot State
No project snapshot selected. Export uses the live evidence card state.
1251
Total Compounds
198
Total Assays
15
Approved Drugs
IC50: 437.0, KI: 977.0, EC50: 5.0, KD: 1.0
Activity Types
pChEMBL Activity Distribution
Top 5 Inhibitors (by pChEMBL)
| Structure | Compound | pChEMBL | Type | Phase |
|---|---|---|---|---|
|
|
No preferred name
CHEMBL372700
|
11.0 | Ki | — |
|
|
No preferred name
CHEMBL59809
|
10.2 | IC50 | — |
|
|
No preferred name
CHEMBL62002
|
10.2 | IC50 | — |
|
|
No preferred name
CHEMBL127006
|
10.1 | IC50 | — |
|
|
No preferred name
CHEMBL473783
|
10.0 | Ki | — |
Approved Drugs
| Structure | Compound | First Approval |
|---|---|---|
|
|
SAFINAMIDE MESYLATE
CHEMBL48582
|
2015 |
|
|
DOLUTEGRAVIR
CHEMBL1229211
|
2013 |
|
|
CITALOPRAM
CHEMBL549
|
1998 |
|
|
FLUVOXAMINE
CHEMBL814
|
1994 |
|
|
SERTRALINE
CHEMBL809
|
1991 |
|
|
ONDANSETRON
CHEMBL46
|
1991 |
|
|
FLUOXETINE
CHEMBL41
|
1987 |
|
|
BUSPIRONE
CHEMBL49
|
1986 |
|
|
PROGESTERONE
CHEMBL103
|
1976 |
|
|
HALOPERIDOL
CHEMBL54
|
1967 |
|
|
THIORIDAZINE
CHEMBL479
|
1962 |
|
|
IMIPRAMINE
CHEMBL11
|
1959 |
|
|
CARBETAPENTANE
CHEMBL73234
|
— |
Source Header