Glutamate NMDA receptor; Grin1/Grin2b · PROTEIN COMPLEX · Rattus norvegicus
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As of 2026-09-13Protein identity stays anchored to UniProt P35439. Use UniProt P35439 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P35439 as the stable identity anchor, then attach disease evidence before program review.
Glutamate receptor ionotropic, NMDA 1
Review this target as Glutamate NMDA receptor; Grin1/Grin2b, mapped to UniProt P35439. ChEMBL maps the protein component as Glutamate receptor ionotropic, NMDA 1. Sequence length is 938 aa.
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This review treats Glutamate NMDA receptor; Grin1/Grin2b as ChEMBL target CHEMBL2096666, mapped to UniProt P35439. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Glutamate NMDA receptor; Grin1/Grin2b |
| Target Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
| UniProt | P35439 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Glutamate receptor ionotropic, NMDA 1 |
| UniProt Accession | P35439 |
| Component Type | Protein |
| Sequence Length | 938 aa |
Glutamate receptor ionotropic, NMDA 1
Review this target as Glutamate NMDA receptor; Grin1/Grin2b, mapped to UniProt P35439. ChEMBL maps the protein component as Glutamate receptor ionotropic, NMDA 1. Sequence length is 938 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL19849 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL19506 | 8.52 | IC50 | 3.0 | Preclinical |
| CHEMBL19419 | 8.4 | IC50 | 4.0 | Preclinical |
| CHEMBL119778 | 8.1 | IC50 | 8.0 | Preclinical |
| CHEMBL305195 | 8.05 | IC50 | 9.0 | Preclinical |
| CHEMBL19404 | 8.05 | IC50 | 9.0 | Preclinical |
| CHEMBL1203902 | 7.96 | IC50 | 11.0 | Preclinical |
| CHEMBL174632 | 7.92 | IC50 | 12.0 | Preclinical |
| CHEMBL19636 | 7.85 | IC50 | 14.0 | Preclinical |
| CHEMBL283753 | 7.82 | IC50 | 15.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 57 | 218 | 5.7 |
| assay format | 7 | 46 | 5.6 |
| protein complex format | 1 | 0 | — |
| tissue-based format | 1 | 19 | 7.5 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 14 | 153 | 5.5 |
| assay format | 2 | 40 | 5.9 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 3 | 0 | — |