Compound Detail
CHEMBL773
GLYCINE 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL773 |
| Name | GLYCINE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | DHMQDGOQFOQNFH-UHFFFAOYSA-N |
10
Targets
33
Activities
3
Assay Types
0
PK Parameters
20
Publications
5
Known Names
17
Indications
Molecular Properties
75.1
MW (Da)
-0.97
ALogP
2
HBA
2
HBD
63.3
PSA (Ų)
0.42
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1982 |
| Availability | Prescription |
| Chirality | Achiral |
Indications
Diarrhea Malnutrition Schizophrenia Asthma Bipolar Disorder Cystic Fibrosis Herpes Labialis Herpes Simplex Hypertension Mental Disorders Obsessive-Compulsive Disorder Psychotic Disorders Respiratory Tract Diseases HIV Infections Alzheimer Disease Cognitive Dysfunction Severe Acute Respiratory Syndrome
ATC Classification
B05CX03
glycine
Level 1: BLOOD AND BLOOD FORMING ORGANS
Level 2: BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS
Activity Summary
EC50 16 meas. best 7.24
IC50 13 meas. best 7.07
Ki 4 meas. best 6.9
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Olfactory receptor 51E2 CHEMBL4523454 | EC50 | 7.24 | 7.24 | 58.0 | 1 |
| Glutamate NMDA receptor CHEMBL1907608 | EC50 | 7.17 | 6.935 | 68.0 | 2 |
| Glutamate NMDA receptor CHEMBL1907608 | IC50 | 7.07 | 6.6433 | 86.0 | 3 |
| Ionotropic glutamate receptor NMDA 1/2D CHEMBL3038506 | EC50 | 7.04 | 7.04 | 91.0 | 1 |
| Unchecked CHEMBL612545 | EC50 | 7.02 | 6.66 | 96.0 | 4 |
| Glutamate NMDA receptor CHEMBL1907608 | Ki | 6.9 | 6.835 | 125.9 | 2 |
| Glutamate NMDA receptor; Grin1/Grin2c CHEMBL2096911 | EC50 | 6.68 | 6.68 | 210.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 6.65 | 5.3675 | 223.0 | 4 |
| Glutamate NMDA receptor; Grin1/Grin2b CHEMBL2096666 | EC50 | 6.62 | 6.62 | 240.0 | 1 |
| Glutamate receptor ionotropic, NMDA 1 CHEMBL330 | IC50 | 6.6 | 5.905 | 250.0 | 2 |
| Glutamate NMDA receptor; Grin1/Grin2a CHEMBL2096680 | EC50 | 6.0 | 6.0 | 990.0 | 1 |
| Sodium- and chloride-dependent glycine transporter 1 CHEMBL2337 | IC50 | 4.5 | 4.5 | 31600.0 | 1 |
| Glycine receptor subunit alpha-1 CHEMBL5845 | EC50 | 4.03 | 4.025 | 94000.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL3885881 | Rattus norvegicus | 193 |
| 22194678 | 10.1371/journal.pcbi.1002310 | Hepatotoxicity | 14 |
| 9438018 | 10.1021/jm970086f | Mus musculus | 10 |
| 20833035 | 10.1016/j.bmcl.2009.05.077 | Mus musculus | 6 |
| 20014752 | 10.1021/tx900326k | Hepatotoxicity | 6 |
| 16759105 | 10.1021/jm0511029 | Solute carrier family 15 member 1 | 4 |
| 10893301 | 10.1021/jm000007r | Unchecked | 4 |
| 27624080 | 10.1016/j.bmcl.2016.09.001 | Large neutral amino acids transporter small subunit 1 | 3 |
| 37468498 | 10.1038/s41467-023-40064-9 | Thromboxane A2 receptor | 2 |
| 17722904 | 10.1021/jm070574f | Glycine receptor subunit alpha-1 | 2 |
| 22931300 | 10.1021/tx300075j | Cytochrome P450 3A4 | 2 |
| 21657271 | 10.1021/jm2001663 | NON-PROTEIN TARGET | 2 |
| 21940173 | 10.1016/j.bmc.2011.08.039 | GABA transporter 4 | 2 |
| 11714598 | 10.1016/s0960-894x(01)00608-4 | Hairpin ribozyme RNA | 2 |
| 7990104 | 10.1021/jm00050a001 | Glutamate NMDA receptor | 2 |
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 2 |
| 21955456 | 10.1016/j.bmc.2011.08.058 | Proton-coupled amino acid transporter 1 | 2 |
| 30048132 | 10.1021/acs.jmedchem.8b01007 | Large neutral amino acids transporter small subunit 1 | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Muscarinic acetylcholine receptor M1 | 2 |
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
Data from ChEMBL 36 via Core Engine