Assay Detail
Binding
CHEMBL882176
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In vitro inhibition of [3H]glycine at NMDA receptor
53
Total Activities
53
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
The glycine site on the NMDA receptor: structure-activity relationships and therapeutic potential.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 53 | 6.53 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL32076 | — | — | 1 | 8.85 |
| CHEMBL31741 | — | — | 1 | 8.70 |
| CHEMBL39881 | — | — | 1 | 8.59 |
| CHEMBL322420 | — | — | 1 | 8.16 |
| CHEMBL287327 | — | — | 1 | 8.11 |
| CHEMBL80741 | — | — | 1 | 8.10 |
| CHEMBL114610 | — | — | 1 | 7.96 |
| CHEMBL133163 | — | — | 1 | 7.72 |
| CHEMBL131409 | — | — | 1 | 7.57 |
| CHEMBL423518 | — | — | 1 | 7.51 |
| CHEMBL22895 | — | — | 1 | 7.50 |
| CHEMBL131520 | — | — | 1 | 7.50 |
| CHEMBL265325 | 1-Aminocyclopropane carboxylic acid | — | 1 | 7.40 |
| CHEMBL105396 | — | — | 1 | 7.00 |
| CHEMBL131842 | — | — | 1 | 7.00 |
| CHEMBL300949 | — | — | 1 | 7.00 |
| CHEMBL132501 | — | — | 1 | 6.96 |
| CHEMBL96426 | — | — | 1 | 6.96 |
| CHEMBL126035 | — | — | 1 | 6.92 |
| CHEMBL293523 | — | — | 1 | 6.89 |
| CHEMBL31344 | — | — | 1 | 6.85 |
| CHEMBL113660 | — | — | 1 | 6.77 |
| CHEMBL773 | GLYCINE | 4.0 | 1 | 6.70 |
| CHEMBL50267 | — | — | 1 | 6.70 |
| CHEMBL1744058 | — | — | 1 | 6.62 |
| CHEMBL285123 | (D)-SERINE | 3.0 | 1 | 6.52 |
| CHEMBL61315 | — | — | 1 | 6.44 |
| CHEMBL131272 | — | — | 1 | 6.40 |
| CHEMBL102574 | — | — | 1 | 6.39 |
| CHEMBL334492 | — | — | 1 | 6.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL32076 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL31741 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL39881 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL322420 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL287327 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL80741 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL114610 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL133163 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL131409 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL423518 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL22895 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL131520 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL265325 | 1-Aminocyclopropane carboxylic acid | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL131842 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL105396 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL300949 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL132501 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL96426 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL126035 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL293523 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL31344 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL113660 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL773 | GLYCINE | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL50267 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1744058 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL285123 | (D)-SERINE | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL61315 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL131272 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL102574 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL334492 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL115225 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL130213 | 6,7-DICHLORO-3-HYDROXY-2-QUINOXALINECARBOXYLIC ACID | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL311389 | 7-CHLOROKYNURENIC ACID | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL277411 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL553701 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL130839 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL23255 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL323335 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL155265 | DNQX | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL131567 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL283819 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL771 | CYCLOSERINE | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL284028 | 2,3-DIHYDROXY-6,7-DICHLOROQUINOXALINE | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL9790 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL325124 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL104297 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL335231 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL337030 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL131244 | 1-AMINOCYCLOBUTANE CARBOXYLIC ACID | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL336423 | — | IC50 | = | 36000.0 | nM | 4.44 |