Compound Detail
CHEMBL132501
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Basic Information
| ChEMBL ID | CHEMBL132501 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MLXQNHQZONNKBM-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
328.8
MW (Da)
3.80
ALogP
2
HBA
2
HBD
73.4
PSA (Ų)
0.77
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate NMDA receptor CHEMBL1907608 | IC50 | 6.96 | 6.96 | 110.0 | 1 |
| Glutamate receptor ionotropic, NMDA 1 CHEMBL330 | IC50 | 6.96 | 6.96 | 110.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, NMDA 1 | IC50 | = | 110.0 | nM | 6.96 | Ability of compound to compete with [3H]glycine for the strychnine-insensitive N... | - |
| Glutamate NMDA receptor | IC50 | = | 110.0 | nM | 6.96 | In vitro inhibition of [3H]glycine at NMDA receptor | 7990104 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/S0960-894X(01)81105-7 | Glutamate receptor ionotropic, NMDA 1 | 1 |
| 7990104 | 10.1021/jm00050a001 | Glutamate NMDA receptor | 1 |
Data from ChEMBL 36 via Core Engine