Glutamate NMDA receptor · PROTEIN COMPLEX GROUP · Rattus norvegicus
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As of 2026-09-13Protein identity stays anchored to UniProt P35439. Use UniProt P35439 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P35439 as the stable identity anchor, then attach disease evidence before program review.
Glutamate receptor ionotropic, NMDA 1
Review this target as Glutamate NMDA receptor, mapped to UniProt P35439. ChEMBL maps the protein component as Glutamate receptor ionotropic, NMDA 1. Sequence length is 938 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Glutamate NMDA receptor as ChEMBL target CHEMBL1907608, mapped to UniProt P35439. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Glutamate NMDA receptor |
| Target Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
| UniProt | P35439 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Glutamate receptor ionotropic, NMDA 1 |
| UniProt Accession | P35439 |
| Component Type | Protein |
| Sequence Length | 938 aa |
Glutamate receptor ionotropic, NMDA 1
Review this target as Glutamate NMDA receptor, mapped to UniProt P35439. ChEMBL maps the protein component as Glutamate receptor ionotropic, NMDA 1. Sequence length is 938 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL540084 | 9.47 | IC50 | 0.34 | Preclinical |
| CHEMBL299281 | 9.12 | IC50 | 0.75 | Preclinical |
| CHEMBL39881 | 9.02 | Ki | 0.96 | Preclinical |
| CHEMBL197208 | 9.0 | Ki | 1.0 | Preclinical |
| CHEMBL59894 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL44793 | 9.0 | IC50 | 1.0 | Clinical |
| CHEMBL383226 | 8.96 | Ki | 1.11 | Preclinical |
| CHEMBL212990 | 8.96 | IC50 | 1.1 | Preclinical |
| CHEMBL1202362 | 8.92 | Ki | 1.2 | Preclinical |
| CHEMBL214758 | 8.92 | IC50 | 1.2 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein complex format | 195 | 364 | 6.0 |
| cell membrane format | 190 | 1,145 | 6.1 |
| assay format | 162 | 634 | 5.9 |
| tissue-based format | 94 | 290 | 6.1 |
| cell-based format | 18 | 58 | 5.8 |
| subcellular format | 11 | 16 | 5.4 |
| cell-free format | 4 | 30 | 5.4 |
| organism-based format | 3 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 91 | 122 | 6.1 |
| tissue-based format | 33 | 16 | 7.4 |
| cell-based format | 23 | 87 | 5.8 |
| cell membrane format | 10 | 21 | 4.7 |
| organism-based format | 4 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell membrane format | 1 | 0 | — |